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Inhibition of MHC class I and class II cell surface expression on bovine endothelial cells upon infection with Cowdria ruminantium

Vachiery Nathalie, Trap Isabelle, Totté Philippe, Martinez Dominique, Bensaïd Albert. 1998. Inhibition of MHC class I and class II cell surface expression on bovine endothelial cells upon infection with Cowdria ruminantium. Veterinary Immunology and Immunopathology, 61 : pp. 37-48.

Journal article ; Article de revue à facteur d'impact
Full text not available from this repository.

Autre titre : Inhibition de l'expression des CMH de classes I et II de la surface cellulaire après infection des cellules endothéliales bovines par Cowdria ruminantium

Abstract : Endothelial cells constitute a main target for Cowdria ruminantium (CR) and can potentially play a role as antigen presenting cells (APC). Therefore, we measured, in vitro, the effect of CR infections on the expression of MHC class I and class II molecules on bovine umbilical endothelial cells (BUEC) and on bovine brain endothelial cells (BBEC). A dramatic inhibition of the expression of IFNy induced MHC class II molecules was observed on BUEC and to a lesser extent on BBEC upon CR infection. This inhibitory effect was also observed on constitutively expressed MHC class I molecules. Part of the reduction of cell surface MHC molecules could be ascribed to their accumulation in intracellular compartments pinpointing a disruption in the transit of these molecules to the surface of the cells. The exact mechanisms of inhibition are not yet known but, as opposed to what is described in other models, the involvement of prostaglandin E2 can be excluded. The results obtained in this study show that endothelial cells have a decreased capacity to express both MHC class I and class II molecules on their surface upon CR infection, thus favouring the escape of this pathogen from the host immune system. (Résumé d'auteur)

Mots-clés Agrovoc : Bovin, Système mhc, Immunité, Inhibition, Infection expérimentale, Maladie bactérienne, Ehrlichia ruminantium

Classification Agris : L73 - Animal diseases

Auteurs et affiliations

  • Vachiery Nathalie
  • Trap Isabelle ORCID: 0000-0002-3429-484X
  • Totté Philippe, CIRAD-EMVT-SANTE ANIMALE (GLP)
  • Martinez Dominique, CIRAD-EMVT-SANTE ANIMALE (GLP)
  • Bensaïd Albert, CIRAD-EMVT-SANTE ANIMALE (GLP)

Autres liens de la publication

  • Document en bibliothèque
  • Localisation du document : BA_PEBA806 [(Bibliothèque de Baillarguet)] ; BA_BR785 [(Bibliothèque de Baillarguet)] ; BA_BR981 [(Bibliothèque de Baillarguet)]

Source : Cirad - Agritrop (https://agritrop.cirad.fr/401315/)

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