Cowdria ruminantum antigens of around 15 kDa are potent inducers of IFN-[gamma]

Gunter Nico, Esteves Isabel, Kandassamy Yane, Martinez Dominique, Bensaïd Albert, Van Kleef Mirinda, Totté Philippe. 2002. Cowdria ruminantum antigens of around 15 kDa are potent inducers of IFN-[gamma]. Annals of the New York Academy of Sciences, 969 : pp. 135-140. International Joint Conference of the Society for Tropical Veterinary Medicine and the Wildlife Disease Association, Pilanesberg National Park, Afrique du Sud, 22 July 2001/27 July 2001.

Journal article ; Article de revue à facteur d'impact
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Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Histoire et philosophie des sciences; Histoire, histoire de l'art, archéologie; Psychologie-éthologie-ergonomie

Abstract : Cellular responses induced in two Creole goats by vaccination with killed Cowdria ruminantium (Cowdria) were confirmed by IFN-[gamma] production and interleukin-2 receptor (IL-2R) expression. Both CD4+ and CD8+ but not WC1+ T cells showed a substantial increase in cell surface expression of IL-2R molecules in response to whole Cowdria lysate. Cowdria (Welgevonden strain) proteins were fractionated using continuous-How electrophoresis and tested for their ability to induce IFN-[gamma] production by PBMC collected three weeks after the first inoculation and one week after the booster injection. Pooled fractions of around 15, 22, and 24 kDa were. found to induce significant IFN-[gamma] production in both vaccinated animals on one of the two occasions. Antigens of around 15 kDa induced substantially higher IFN-[gamma] production than any other fractions in both animals. These pilot experiments pave the way towards the identification of proteins/genes that have potential for the development of a recombinant vaccine against heartwater. (Résumé d'auteur)

Classification Agris : L73 - Animal diseases

Auteurs et affiliations

  • Gunter Nico, OVI (ZAF)
  • Esteves Isabel, OVI (ZAF)
  • Martinez Dominique, CIRAD-EMVT-SANTE ANIMALE (GLP)
  • Van Kleef Mirinda, OVI (ZAF)

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Source : Cirad - Agritrop (

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