Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis

Maillard Jean-Charles, Berthier David, Chantal Isabelle, Thevenon Sophie, Sidibé Issa, Stachurski Frédéric, Belemsaga Désiré M.A., Razafindraibe Hanta, Elsen Jean-Michel. 2003. Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis. Genetics Selection Evolution, 35suppl.1, S193-S200 International Symposium on Candidate Genes for Animal Health. 2, Montpellier, France, 16 August 2002/18 August 2002.

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Abstract : Bovine dermatophilosis is a severe skin infection of tropical ruminants inducing a severe loss in productivity and a 15% mortality rate. This disease is caused by the actinomycete bacterium Dermatophilus congolensis associated with the tick Amblyomma variegatum. Currently there are no prospects for a vaccine, and acaricide or antibiotic control is hampered by the development of chemoresistance. Animal breeders have observed that dermatophilosis susceptibility seems to be determined genetically, and we previously identified a BoLA-DRB3DQB class II haplotype marker for high (R2 = 0.96) susceptibility to the disease. With this marker, we developed a successful eugenic selection procedure for zebu Brahman cattle in Martinique (FWI). Over a period of five years, a marked reduction in disease prevalence, from 0.76 to 0.02 was achieved, and this low level has been maintained over the last two years. The selection procedure, based on a genetic marker system targeting the highly polymorphic BoLA locus, eliminates only those individuals which are at the highest risk of contracting the disease. In the present work, we discuss the properties of this system, including the "heterozygote advantage" and the "frequency dependence" theories, and examine their involvement in the biological mechanisms at the host/pathogen interface. We speculate on the exact role of the MHC molecules in the control of the disease, how the natural selection pressure imposed by the pathogens selectively maintains MHC diversity, and how our results can be practically applied for integrated control of dermatophilosis in developing countries. (Résumé d'auteur)

Mots-clés Agrovoc : Maladie bactérienne, Bovin, Résistance aux maladies, Marqueur génétique, Locus

Mots-clés complémentaires : Gène de résistance

Classification Agris : L10 - Animal genetics and breeding

Auteurs et affiliations

  • Maillard Jean-Charles, CIRAD-EMVT-SANTE ANIMALE (FRA)
  • Berthier David, CIRAD-EMVT-SANTE ANIMALE (FRA) ORCID: 0000-0002-3283-6588
  • Chantal Isabelle, CIRAD-EMVT-SANTE ANIMALE (FRA) ORCID: 0000-0002-3429-484X
  • Sidibé Issa, CIRDES (BFA)
  • Stachurski Frédéric, CIRAD-EMVT-ECONAP (BFA)
  • Belemsaga Désiré M.A., CIRDES (BFA)
  • Razafindraibe Hanta, CENDRADERU (MDG)
  • Elsen Jean-Michel, INRA (FRA)

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