Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats

Le Bon Anne-Marie, Vernevaut Marie-France, Guénot Lucien, Kahane Rémi, Auger Jacques, Arnault Ingrid, Haffner Thomas, Siess Marie-Hélène. 2003. Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats. Journal of Agricultural and Food Chemistry, 51 (26) : pp. 7617-7623.

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Abstract : The anticarcinogenic effect of garlic has been demonstrated in both epidemiologic and experimental studies. In this study, possible mechanisms involved in the anticarcinogenic effect of garlic consumption were assessed by determining its capacity to alter drug metabolizing enzymes, in relation with its alliin content. Rats were fed a diet for 2 weeks containing 5% garlic powders produced from bulbs grown on soils with different levels of sulfate fertilization and therefore containing differing amounts of alliin. Activities of several hepatic enzymes, which are important in carcinogen metabolism such cytochromes P450 (CYP) and phase If enzymes, were determined. Garlic consumption slightly increased ethoxyresorufin O-deethylase and CYP 1A2 levels. In contrast, garlic consumption decreased CYP 2E1 activity and the level of the corresponding isoform. UDP glucuronosyl transferase and glutathion S-transferase activities were increased by garlic powders. The alliin content of the garlic powders was positively correlated with UGT activity although not with other activities. Effects produced by garlic consumption were qualitatively similar to that of diallyl disulfide, a sulfur compound that has been extensively studied. These data could partially explain the chemoprotective effect of garlic. (Résumé d'auteur)

Mots-clés Agrovoc : Ail, Allium sativum, Enzyme, Rat, Foie, Santé, Médicament, Propriété pharmacologique

Classification Agris : Q04 - Food composition
S01 - Human nutrition - General aspects

Auteurs et affiliations

  • Le Bon Anne-Marie, INRA (FRA)
  • Vernevaut Marie-France, INRA (FRA)
  • Guénot Lucien, INRA (FRA)
  • Kahane Rémi, CIRAD-FLHOR-PMH (FRA) ORCID: 0000-0001-5492-2834
  • Auger Jacques, Université François Rabelais (FRA)
  • Arnault Ingrid, Université François Rabelais (FRA)
  • Haffner Thomas, Lichtwer Pharma AG (DEU)
  • Siess Marie-Hélène, INRA (FRA)

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