Genetic diversity of Plasmodium vivax isolates from Azerbaijan

Leclerc Marie Claude, Menegon Michela, Cligny Alexandra, Noyer Jean-Louis, Mammadov Suleyman, Aliyev Namig, Gasimov Elkhan, Majori Giancarlo, Severini Carlo. 2004. Genetic diversity of Plasmodium vivax isolates from Azerbaijan. Malaria Journal, 3 (40) : pp. 1-10.

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Abstract : Background: Plasmodium vivax, although causing a less serious disease than Plasmodium falciparum, is the most widespread of the four human malarial species. Further to the recent recrudescence of P. vivax cases in the Newly Independent States (NIS) of central Asia, a survey on the genetic diversity and dissemination in Azerbaijan was undertaken. Azerbaijan is at the crossroads of Asia and, as such, could see a rise in the number of cases, although an effective malaria control programme has been established in the country. Methods: Thirty-six P. vivax isolates from Central Azerbaijan were characterized by analysing the genetic polymorphism of the circumsporozoite protein (CSP) and the merozoite surface protein I (MSP-I) genes, using PCR amplifications and amplicons sequencing. Results: Analysis of CSP sequences showed that all the processed isolates belong to the VK 210 type, with variations in the alternation of alanine residue (A) or aspartic acid residue (D) in the repeat motif GDRA(A/D)GQPA along the sequence. As far as MSP-I genotyping is concerned, it was found that the majority of isolates analysed belong to Belem and Sal I types. Five recombinant isolates were also identified. Combined analysis with the two genetic markers allowed the identification of 19 plasmodial sub-types. Conclusion: The results obtained in the present study indicate that there are several P. vivax clones circulating in Azerbaijan and, consequently, a careful malaria surveillance could be of paramount importance to identify, at early stage, the occurrence of possible P. vivax malaria outbreaks. (Résumé d'auteur)

Mots-clés Agrovoc : Plasmodium vivax, Variation génétique, Transmission des maladies, Technique analytique, Identification, Surveillance épidémiologique, Malaria

Mots-clés géographiques Agrovoc : Thaïlande

Classification Agris : T10 - Occupational diseases and hazards
U30 - Research methods

Auteurs et affiliations

  • Leclerc Marie Claude, CNRS (FRA)
  • Menegon Michela, Istituto Superiore di Sanita (ITA)
  • Cligny Alexandra, IRD (FRA)
  • Noyer Jean-Louis, CIRAD-AMIS-BIOTROP (FRA) ORCID: 0000-0002-7389-5621
  • Mammadov Suleyman, Republican Center of Hygiene and Epidemiology (AZE)
  • Aliyev Namig, National Research Institute of Medical Prevention (AZE)
  • Gasimov Elkhan
  • Majori Giancarlo, Istituto Superiore di Sanita (ITA)
  • Severini Carlo, Istituto Superiore di Sanita (ITA)

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