Chemo-enzymatic synthesis of N-arachidonoyl glycine

Goujard Laurent, Figueroa-Espinoza Maria-Cruz, Villeneuve Pierre. 2004. Chemo-enzymatic synthesis of N-arachidonoyl glycine. Biotechnology Letters, 26 (15) : pp. 1211-1216.

Journal article ; Article de revue à facteur d'impact
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Abstract : N-Arachidonoyl glycine was synthesized in a chemo-enzymatic process where glycine tert-butyl ester was acylated by arachidonic acid and the resulted ester was then de-protected to give the final product. Among various lipases tested and chosen for their ability to cleave fatty amides, that from Candida antarctica B gave the best results resulting in a 39% hydrolysis after 24 h. This enzyme was then used for the reverse N-acylation synthesis and gave a 75% product formation after 24 h using methyl ester of arachadonic acid as acyl donor and acetonitrile as solvent. Direct acylation of glycine gave less than 10% yield. (Résumé d'auteur)

Mots-clés Agrovoc : Glycine (acide aminé), Acide arachidonique, Biocatalyseur, Butyrate (ester), Synthèse chimique, Estérase, Activité enzymatique, Candida albicans, Acylation, Lipase

Mots-clés complémentaires : Synthèse enzymatique

Classification Agris : Q02 - Food processing and preservation
Q60 - Processing of non-food or non-feed agricultural products

Auteurs et affiliations

  • Figueroa-Espinoza Maria-Cruz, CIRAD-AMIS-AGROALIMENTAIRE (FRA)
  • Villeneuve Pierre, CIRAD-AMIS-AGROALIMENTAIRE (FRA) ORCID: 0000-0003-1685-1494

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Source : Cirad - Agritrop (

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