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Recombinant capriposviruses expressing proteins of bluetongue virus : evaluation of immune response and protection in small ruminants

Perrin Aurélie, Albina Emmanuel, Breard Emmanuel, Sailleau Corinne, Prome Sylvie, Grillet Colette, Kwiatek Olivier, Russo Pierre, Thiéry Richard, Zientara Stéphan, Cetre-Sossah Catherine. 2007. Recombinant capriposviruses expressing proteins of bluetongue virus : evaluation of immune response and protection in small ruminants. In : Does control of animal infectious risks offer a new international perspective ? : proceedings of the 12th International Conference of the Association of Institutions of Tropical Veterinary Medicine, Montpellier, France, 20-22 August 2007. Camus Emmanuel (ed.), Cardinale Eric (ed.), Dalibard Christophe (ed.), Martinez Dominique (ed.), Renard Jean-François (ed.), Roger François (ed.). CIRAD. Montpellier : CIRAD, pp. 187-190. ISBN 978-2-87614-650-1 International Conference of the Association of Institutions of Tropical Veterinary Medicine. 12, Montpellier, France, 20 August 2007/22 August 2007.

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Abstract : Bluetongue is an infectious arthropod-borne viral disease affecting sheep, domestic and wild ruminants caused by Bluetongue Virus (BTV) and transmitted by few species of Culicoides (Diptera: Ceratopogonidae). Since 1998, outbreaks of BT involving 6 distinct serotypes have occurred in the Mediterranean basin. The only BTV vaccines currently available are serotype specific. Objectives: The development of recombinants capripoxvirus for protective immunization of ruminants against bluetongue virus (BTV) infection is described here. Methodology: Sheep (n=11) and goats (n=4) were immunized with bluetongue recombinant capripoxvirus (BTV-Cpox) expressing individually four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of Bluetongue virus serotype 2 (BTV-2). Results: Seroconversion was observed against NS3, VP7 and VP2 in both groups of animals. A specific BTV antigens lymphoproliferation observed in goats corroborates with a partial protection in sheep challenged with a virulent strain of BTV-2.

Classification Agris : L73 - Animal diseases

Auteurs et affiliations

  • Perrin Aurélie, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
  • Albina Emmanuel, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
  • Breard Emmanuel, AFSSA (FRA)
  • Sailleau Corinne, AFSSA (FRA)
  • Prome Sylvie, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
  • Grillet Colette, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
  • Kwiatek Olivier, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
  • Russo Pierre, AFSSA (FRA)
  • Thiéry Richard, AFSSA (FRA)
  • Zientara Stéphan, AFSSA (FRA)
  • Cetre-Sossah Catherine, CIRAD-BIOS-UPR Contrôle des maladies (FRA)

Autres liens de la publication

Source : Cirad - Agritrop (https://agritrop.cirad.fr/541570/)

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