Genetics of sex determination in Tilapiine species

Cnaani Avner, Lee B.Y., Zilberman N., Ozouf-Costaz Catherine, Hulata Gideon, Ron Micha, D'Hont Angélique, Baroiller Jean-François, D'Cotta Helena, Penman D.J., Tomasino E., Coutanceau Jean-Pierre, Pepey Elodie, Shirak A., Kocher Thomas D.. 2008. Genetics of sex determination in Tilapiine species. Sexual Development, 2 (1) : 43-54.

Résumé : We identified DNA markers linked to sex determining genes in six closely related species of tilapiine fishes. The mode of sex determination differed among species. In Oreochromis karongae and Tilapia mariae the sex-determining locus is on linkage group (LG) 3 and the female is heterogametic (WZ-ZZ system). In O. niloticus and T. zillii the sex-determining locus is on LG1 and the male is heterogametic (XX-XY system). A more complex pattern was observed in O. aureus and O. mossambicus, in which markers on both LG1 and LG3 were associated with sex. We found evidence for sex-linked lethal effects on LG1, as well as interactions between loci in the two linkage groups. Comparison of genetic and physical maps demonstrated a broad region of recombination suppression harboring the sex-determining locus on LG3. Sex-specific recombination suppression was found in the female heterogametic sex. Sequence analysis showed the accumulation of repetitive elements in this region. Phylogenetic analysis suggests that at least two transitions in the mode of sex determination have occurred in this clade. This variation in sex determination mechanisms among closely related species makes tilapias an excellent model system for studying the evolution of sex chromosomes in vertebrates.

Mots-clés Agrovoc : tilapia (genre), Oreochromis, détermination du sexe, différenciation sexuelle, marqueur génétique, chromosome, paramètre génétique, Cichlidae, recombinaison, gamète, phylogénie

Classification Agris : L10 - Génétique et amélioration des animaux
L53 - Physiologie animale - Reproduction
M12 - Production de l'aquaculture

Champ stratégique Cirad : Axe 1 (2005-2013) - Intensification écologique

Auteurs et affiliations

• Cnaani Avner, University of New Hampshire (USA)
• Lee B.Y., University of New Hampshire (USA)
• Zilberman N., ARO (ISR)
• Ozouf-Costaz Catherine, MNHN (FRA)
• Hulata Gideon, ARO (ISR)
• Ron Micha, ARO (ISR)
• D'Hont Angélique, CIRAD-BIOS-UMR DAP (FRA)
• Baroiller Jean-François, CIRAD-PERSYST-UPR Aquaculture (FRA) ORCID: 0000-0002-0992-1725
• D'Cotta Helena, CIRAD-PERSYST-UPR Aquaculture (FRA) ORCID: 0000-0003-2739-3476
• Penman D.J., University of Stirling (GBR)
• Tomasino E., Cornell University (USA)
• Coutanceau Jean-Pierre, MNHN (FRA)
• Pepey Elodie, CIRAD-PERSYST-UPR Aquaculture (FRA)
• Shirak A., ARO (ISR)
• Kocher Thomas D., University of New Hampshire (USA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/543869/)

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