Pharmaceutical proteins in plants: A strategic genetic engineering approach for the production of tuberculosis antigens

Frutos Roger, Denise Hubert, Vivares Christian, Neuhaus Jean-Marc, Vitale Sandro, Pedrazzini Emmanuela, Ma Julian, Dix Phil, Gray John, Pezzotti Mario, Conrad Udo, Robinson David. 2008. Pharmaceutical proteins in plants: A strategic genetic engineering approach for the production of tuberculosis antigens. Annals of the New York Academy of Sciences, 1149 : pp. 275-280. Biennial Conference of the Society for Tropical Veterinary Medicine. 9, Mexico, Mexique, 17 June 2007/22 June 2007.

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Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Histoire et philosophie des sciences; Histoire, histoire de l'art, archéologie; Psychologie-éthologie-ergonomie

Abstract : Tuberculosis (TB) is a re-emerging disease that is considered a major human health priority aswell as an important disease of livestock. TB is also a zoonosis, and Mycobacterium tuberculosis and M. bovis, the human and bovine causative agents, respectively, are very closely related. Protection against TB is essentially achieved through vaccination with the Bacille Calmetle-Guerin (BCG) strain of M. bovis. Protection is, however, incomplete, and novel improved vaccines are currently under investigation. Production of protective antigens in transgenic plants, or "pharming," is a promising emerging approach, and a zoonosis-like TB is a good model for investigating the potential of this approach. Pharma-Planta, a European Commission-funded project and consortium, was set up to address this topic, within which a component is aimed at assessing the production efficacy and stability of the TB antigens in different compartments of the plant cell. This article ismeant to introduce this promising approach for veterinary medicine by describing the ongoing project and its specific genetic engineering strategy. (Résumé d'auteur)

Mots-clés Agrovoc : Tuberculose, Mycobacterium tuberculosis, Mycobacterium bovis, Plante transgénique, Vaccin, Protéine végétale, Antigène, Projet de recherche, Génie génétique

Classification Agris : L73 - Animal diseases

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Denise Hubert, Université Blaise Pascal (FRA)
  • Vivares Christian, Université Blaise Pascal (FRA)
  • Neuhaus Jean-Marc, Université de Neuchâtel (CHE)
  • Vitale Sandro, Istituto di Biologia e Biotecnologia Agraria (ITA)
  • Pedrazzini Emmanuela, Istituto di Biologia e Biotecnologia Agraria (ITA)
  • Ma Julian
  • Dix Phil, University of Ireland (IRL)
  • Gray John, University of Cambridge (GBR)
  • Pezzotti Mario, Universita di Verona (ITA)
  • Conrad Udo, Universität Gatersleben (DEU)
  • Robinson David, University of Heidelberg (DEU)

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