Secretome of animal trypanosomes: From a standard method toward new diagnostic and therapeutic targets

Holzmuller Philippe, Grébaut Pascal, Peltier Jean-Benoît, Brizard Jean-Paul, Perrone Trina, Gonzatti Marisa, Bengaly Zakaria, Rossignol Michel, Aso Pedro J., Vincendeau Philippe, Cuny Gérard, Boulangé Alain, Frutos Roger. 2008. Secretome of animal trypanosomes: From a standard method toward new diagnostic and therapeutic targets. Annals of the New York Academy of Sciences, 1149 : pp. 337-342. Biennial Conference of the Society for Tropical Veterinary Medicine. 9, Mexico, Mexique, 17 June 2007/22 June 2007.

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Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Histoire et philosophie des sciences; Histoire, histoire de l'art, archéologie; Psychologie-éthologie-ergonomie

Abstract : Animal trypanosomosis is one of the most severe constraints to agricultural development in sub-Saharan Africa and is also an important disease of livestock in Latin America and Asia. The causative agents are various species of protozoan parasites belonging to the genus Trypanosoma, among which T. congolense and T. evansi are the major pathogenic species. The extracellular position of trypanosomes obliges us to consider both the parasite and its excreted/secreted factors in the course of the physiopathologic process. The advent of proteomics led us to propose a comparative approach of the proteome (i.e., the whole parasite content) and the secretome (i.e., naturally excreted/secreted molecules) of T. congolense and T. evansi with particular attention to common and specific molecules between strains of differing virulence and pathogenicity. The molecular identification of differentially expressed trypanosome molecules correlated with either the virulence process or the pathogenicity will provide new potential molecular targets for improved field diagnosis and chemotherapy of animal trypanosomosis. (Résumé d'auteur)

Mots-clés Agrovoc : Trypanosoma, Trypanosoma evansi, Trypanosoma congolense, Pouvoir pathogène, Sécrétion, Protéine microbienne, Protéine microbiologique, Expression des gènes

Mots-clés complémentaires : Protéomique

Classification Agris : L73 - Animal diseases

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Holzmuller Philippe, CIRAD-BIOS-UMR TRYPANOSOMES (FRA) ORCID: 0000-0002-8919-9081
  • Grébaut Pascal, IRD (FRA)
  • Peltier Jean-Benoît, INRA (FRA)
  • Brizard Jean-Paul, CNRS (FRA)
  • Perrone Trina, IVIC (VEN)
  • Gonzatti Marisa, Universidad Simón Bolívar (VEN)
  • Bengaly Zakaria, CIRDES (BFA)
  • Rossignol Michel, INRA (FRA)
  • Aso Pedro J., Universidad Simón Bolívar (VEN)
  • Vincendeau Philippe, Université de Bordeaux II (FRA)
  • Cuny Gérard, IRD (FRA)

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