Tsetse flies, trypanosomes, humans and animals: what is proteomics revealing about their crosstalks?

Holzmuller Philippe, Grébaut Pascal, Cuny Gérard, Biron David George. 2010. Tsetse flies, trypanosomes, humans and animals: what is proteomics revealing about their crosstalks?. Expert Review of Proteomics, 7 (1) : pp. 113-126.

Journal article ; Article de revue à facteur d'impact
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Abstract : Human and animal African trypanosomoses, or sleeping sickness and Nagana, are neglected vector-borne parasitic diseases caused by protozoa belonging to the Trypanosoma genus. Advances in proteomics offer new tools to better understand host-vector-parasite crosstalks occurring during the complex parasitic developmental cycle, and to determine the outcome of both transmission and infection. In this review, we summarize proteomics studies performed on African trypanosomes and on the interactions with their vector and mammalian hosts. We discuss the contributions and pitfalls of using diverse proteomics tools, and argue about the interest of pathogenoproteomics, both to generate advances in basic research on the best knowledge and understanding of host-vector-pathogen interactions, and to lead to the concrete development of new tools to improve diagnosis and treatment management of trypanosomoses in the near future. (Résumé d'auteur)

Mots-clés Agrovoc : Trypanosoma, Glossina, Vecteur de maladie, Mammifère, Genre humain, Relation hôte pathogène, Expression des gènes, Protéine, Génie génétique

Mots-clés complémentaires : Protéomique

Classification Agris : L72 - Pests of animals
L73 - Animal diseases
U30 - Research methods

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Holzmuller Philippe, CIRAD-BIOS-UMR TRYPANOSOMES (FRA) ORCID: 0000-0002-8919-9081
  • Grébaut Pascal, IRD (FRA)
  • Cuny Gérard, IRD (FRA)
  • Biron David George

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