Association studies in QTL regions linked to bovine trypanotolerance in a West African crossbred population

Dayo Guiguigbaza-Kossigan, Gautier Mathieu, Berthier David, Poivey Jean-Paul, Sidibé Issa, Bengaly Zakaria, Eggen André, Boichard D., Thevenon Sophie. 2012. Association studies in QTL regions linked to bovine trypanotolerance in a West African crossbred population. Animal Genetics, 43 (2) : pp. 123-132.

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Quartile : Q1, Sujet : AGRICULTURE, DAIRY & ANIMAL SCIENCE / Quartile : Q2, Sujet : GENETICS & HEREDITY

Abstract : African animal trypanosomosis is a parasitic blood disease transmitted by tsetse flies and is widespread in sub-Saharan Africa. West African taurine breeds have the ability, known as trypanotolerance, to limit parasitaemia and anaemia and remain productive in enzootic areas. Several quantitative trait loci (QTL) underlying traits related to trypanotolerance have been identified in an experimentally infected F2 population resulting from a cross between taurine and zebu cattle. Although this information is highly valuable, the QTL remain to be confirmed in populations subjected to natural conditions of infection, and the corresponding regions need to be refined. In our study, 360 West African cattle were phenotyped for the packed cell volume control under natural conditions of infection in south-western Burkina Faso. Phenotypes were assessed by analysing data from previous cattle monitored over 2 years in an area enzootic for trypanosomosis. We further genotyped for 64 microsatellite markers mapping within four previously reported QTL on BTA02, BTA04, BTA07 and BTA13. These data enabled us to estimate the heritability of the phenotype using the kinship matrix between individuals computed from genotyping data. Thus, depending on the estimators considered and the method used, the heritability of anaemia control ranged from 0.09 to 0.22. Finally, an analysis of association identified an allele of the MNB42 marker on BTA04 as being strongly associated with anaemia control, and a candidate gene, INHBA, as being close to that marker. (Résumé d'auteur)

Mots-clés Agrovoc : Bovin, Trypanosomose, Locus des caractères quantitatifs, Résistance aux maladies, Résistance génétique

Mots-clés géographiques Agrovoc : Burkina Faso, Afrique occidentale

Mots-clés complémentaires : QTL

Classification Agris : L73 - Animal diseases
L10 - Animal genetics and breeding

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Dayo Guiguigbaza-Kossigan, CIRAD-BIOS-UMR TRYPANOSOMES (FRA)
  • Gautier Mathieu, INRA (FRA)
  • Berthier David, CIRAD-BIOS-UMR TRYPANOSOMES (FRA) ORCID: 0000-0002-3283-6588
  • Poivey Jean-Paul, CIRAD-ES-UMR SELMET (TWN)
  • Sidibé Issa, CIRDES (BFA)
  • Bengaly Zakaria, CIRDES (BFA)
  • Eggen André, INRA (FRA)
  • Boichard D., INRA (FRA)

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