An evaluation of melarsomine hydrochloride efficacy for parasitological cure in experimental infection of dairy cattle with Trypanosoma evansi in Thailand

Desquesnes Marc, Kamyingkird Ketsarin, Vergne Timothée, Sarataphan Nachai, Pranee Rodtian, Jittapalapong Sathaporn. 2011. An evaluation of melarsomine hydrochloride efficacy for parasitological cure in experimental infection of dairy cattle with Trypanosoma evansi in Thailand. Parasitology, 138 : 1134-1142.

Quartile : Q1, Sujet : PARASITOLOGY

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Melarsomine hydrochloride can cure Trypanosoma evansi infection in camels at a dose of 0·25 mg/kg, but at that dose relapses occur in cattle. In our study, the efficacy of an intramuscular injection of melarsomine hydrochloride at 0·5 mg/kg was assessed in 3 normal and 3 splenectomized dairy cattle experimentally infected with a stock of T. evansi from Thailand. The animals were monitored for 5 months by haematocrit centrifugation, blood- or cerebrospinal fluid-mouse inoculation, polymerase chain reaction, the card agglutination test (CATT) for T. evansi, and the enzyme-linked immunosorbent assay?T. evansi. Parasitological and DNA tests became and remained negative just after treatment. By the end of the experiment, CATTwas negative and ELISA scores were below or very close to the cut-off value. One of the splenectomized cattle died from anaplasmosis during the experiment, but tested negative for surra. It was concluded that the parasites had been cleared from the cattle, and melarsomine hydrochloride at 0·5 mg/kg can be recommended for treatment against T. evansi infection in dairy cattle in Thailand. Further work is necessary to validate the efficacy of the treatment in the event of confirmed CSF-infection.

Mots-clés Agrovoc : Trypanosoma evansi, bovin laitier

Mots-clés géographiques Agrovoc : Thaïlande

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Desquesnes Marc, CIRAD-BIOS-UMR INTERTRYP (THA) ORCID: 0000-0002-7665-2422
• Kamyingkird Ketsarin, Kasetsart University (THA)
• Vergne Timothée, CIRAD-ES-UPR AGIRs (FRA)
• Sarataphan Nachai, Department of Livestock Development (THA)
• Pranee Rodtian, Department of Livestock Development (THA)
• Jittapalapong Sathaporn, Kasetsart University (THA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/560770/)

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