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Evolution and population structure of Salmonella enterica serovar Newport

Sangal Vartul, Harbottle Heather, Mazzoni Camila J., Helmuth Reiner, Guerra Beatriz, Didelot Xavier, Paglietti Bianca, Rabsch Wolfgang, Brisse Sylvain, Weill François-Xavier, Roumagnac Philippe, Achtman Mark. 2010. Evolution and population structure of Salmonella enterica serovar Newport. Journal of Bacteriology, 192 (24) : pp. 6465-6476.

Journal article ; Article de revue à facteur d'impact
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Quartile : Q1, Sujet : MICROBIOLOGY

Abstract : Salmonellosis caused by Salmonella enterica serovar Newport is a major global public health concern, particularly because S. Newport isolates that are resistant to multiple drugs (MDR), including thirdgeneration cephalosporins (MDR-AmpC phenotype), have been commonly isolated from food animals. We analyzed 384 S. Newport isolates from various sources by a multilocus sequence typing (MLST) scheme to study the evolution and population structure of the serovar. These were compared to the population structure of S. enterica serovars Enteritidis, Kentucky, Paratyphi B, and Typhimurium. Our S. Newport collection fell into three lineages, Newport-I, Newport-II, and Newport-III, each of which contained multiple sequence types (STs). Newport-I has only a few STs, unlike Newport-II or Newport-III, and has possibly emerged recently. Newport-I is more prevalent among humans in Europe than in North America, whereas Newport-II is preferentially associated with animals. Two STs of Newport-II encompassed all MDR-AmpC isolates, suggesting recent global spread after the acquisition of the blaCMY-2 gene. In contrast, most Newport-III isolates were from humans in North America and were pansusceptible to antibiotics. Newport was intermediate in population structure to the other serovars, which varied from a single monophyletic lineage in S. Enteritidis or S. Typhimurium to four discrete lineages within S. Paratyphi B. Both mutation and homologous recombination are responsible for diversification within each of these lineages, but the relative frequencies differed with the lineage. We conclude that serovars of S. enterica provide a variety of different population structures. (Résumé d'auteur)

Mots-clés Agrovoc : Salmonella, Sérotype, Dynamique des populations, Génétique des populations, Animal, Genre humain

Mots-clés géographiques Agrovoc : États-Unis, Europe, Allemagne, France

Mots-clés complémentaires : Salmonella enterica

Classification Agris : L72 - Pests of animals
Q53 - Feed contamination and toxicology

Champ stratégique Cirad : Axe 3 (2005-2013) - Alimentation accessible et de qualité

Auteurs et affiliations

  • Sangal Vartul, Max-Planck Institut für Infektionsbiologie (DEU)
  • Harbottle Heather, Center for Veterinary Medecine-US Food and Drug Administration (USA)
  • Mazzoni Camila J., UCC (IRL)
  • Helmuth Reiner, Federal Institute for risk assesment (BfR) (DEU)
  • Guerra Beatriz, Federal Institute for risk assesment (BfR) (DEU)
  • Didelot Xavier, University of Oxford (GBR)
  • Paglietti Bianca, Universita di Sassari (ITA)
  • Rabsch Wolfgang, Robert Koch-Institute (DEU)
  • Brisse Sylvain, Institut Pasteur (FRA)
  • Weill François-Xavier, Institut Pasteur (FRA)
  • Roumagnac Philippe, CIRAD-BIOS-UMR BGPI (FRA) ORCID: 0000-0001-5002-6039
  • Achtman Mark, UCC (IRL)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/563438/)

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