First report of the L1014S kdr mutation in wild populations of Anopheles gambiae M and S molecular forms in Burkina Faso (West Africa)

Namountougou Moussa, Diabaté Abdoulaye, Etang Josiane, Bass Chris, Sawadogo Simon P., Gnankine Olivier, Baldet Thierry, Martin Thibaud, Chandre Fabrice, Simard Frédéric, Dabiré Roch Kounbobr. 2013. First report of the L1014S kdr mutation in wild populations of Anopheles gambiae M and S molecular forms in Burkina Faso (West Africa). Acta Tropica, 125 (2) : pp. 123-127.

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Quartile : Q1, Sujet : TROPICAL MEDICINE / Quartile : Q2, Sujet : PARASITOLOGY

Abstract : We investigated the occurrence of the L1014F and L1014S kdr mutations in malaria vector populations in Burkina Faso (West Africa). A cross-sectional survey was conducted at 10 sites all located in cotton cultivation areas which are assumed to be the major insecticide resistance selection foci in Burkina Faso. The hot ligation method was used to detect the two kdr mutations in field collected Anopheles gambiae s.l. samples. For the first time in Burkina Faso the L1014S mutation was identified in both M and S forms of An. gambiae s.s. populations collected from the site of Koupela in the central-eastern region at low frequency. Furthermore, the L1014S mutation was also found in one specimen of An. arabiensis collected from the Dano site. The data generated in this study provides additional evidence of the spread of the L1014S mutation into An. gambiae s.l. populations in West Africa. It is now important to evaluate the role of the L1014S mutation in the pyrethroid resistance phenotype and assess its potential impact on the efficacy of pyrethroid-based control measures in West Africa where several resistance mutations now coexist. (Résumé d'auteur)

Mots-clés Agrovoc : Anopheles gambiae, Mutation, Résistance génétique, Pyréthrine, Résistance aux pesticides, Malaria, Vecteur de maladie

Mots-clés géographiques Agrovoc : Burkina Faso

Classification Agris : L72 - Pests of animals
L73 - Animal diseases

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Namountougou Moussa, IRSS (BFA)
  • Diabaté Abdoulaye, Institut de Recherche en Sciences de la Santé (BFA)
  • Etang Josiane, OCEAC (CMR)
  • Bass Chris, Rothamsted Experiment Station (GBR)
  • Sawadogo Simon P., IRSS (BFA)
  • Gnankine Olivier, Université de Ouagadougou (BFA)
  • Baldet Thierry, CIRAD-BIOS-UMR CMAEE (FRA) ORCID: 0000-0003-2979-9517
  • Martin Thibaud, CIRAD-PERSYST-UPR HortSys (FRA)
  • Chandre Fabrice, IRD (FRA)
  • Simard Frédéric, IRSS (BFA)
  • Dabiré Roch Kounbobr, Institut de Recherche en Sciences de la Santé (BFA)

Source : Cirad - Agritrop (

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