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First attempt to validate human IgG antibody response to Nterm-34kDa salivary peptide as biomarker for evaluating exposure to Aedes aegypti bites

Elanga Emmanuel, Doucoure Souleymane, Damien Georgia, Mouchet François, Drame Papa Makhtar, Cornelie Sylvie, Noukpo Herbert, Yamadjako Sandra, Djènontin Armel, Moiroux Nicolas, Missé Dorothée, Akogbeto Martin, Corbel Vincent, Henry Marie-Claire, Chandre Fabrice, Baldet Thierry, Remoue Franck. 2012. First attempt to validate human IgG antibody response to Nterm-34kDa salivary peptide as biomarker for evaluating exposure to Aedes aegypti bites. PLoS Neglected Tropical Diseases, 6 (11):e1905, 7 p.

Journal article ; Article de revue à facteur d'impact Revue en libre accès total
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Quartile : Q1, Sujet : TROPICAL MEDICINE / Quartile : Q1, Sujet : PARASITOLOGY

Abstract : Background: Much effort is being devoted for developing new indicators to evaluate the human exposure to Aedes mosquito bites and the risk of arbovirus transmission. Human antibody (Ab) responses to mosquito salivary components could represent a promising tool for evaluating the human-vector contact. Methodology/Principal findings: To develop a specific biomarker of human exposure to Aedes aegypti bites, we measured IgG Ab response to Ae. aegypti Nterm-34 kDa salivary peptide in exposed children in 7 villages of Southern Benin (West Africa). Results showed that specific IgG response presented high inter-individual heterogeneity between villages. IgG response was associated with rainfall and IgG level increased from dry (low exposure) to rainy (high exposure) seasons. These findings indicate that IgG Ab to Nterm-34 kDa salivary peptide may represent a reliable biomarker to detect variation in human exposure to Ae. aegypti bites. Conclusion/Significance: This preliminary study highlights the potential use of Ab response to this salivary peptide for evaluating human exposure to Ae. aegypti. This biomarker could represent a new promising tool for assessing the risk of arbovirus transmission and for evaluating the efficacy of vector control interventions. (Résumé d'auteur)

Mots-clés Agrovoc : Immunodiagnostic, Salive, Technique immunologique, Genre humain, Aedes aegypti, Vecteur de maladie, Virus des animaux, Alphavirus, Flavivirus

Mots-clés géographiques Agrovoc : Bénin

Mots-clés complémentaires : Arbovirose

Classification Agris : L72 - Pests of animals
L73 - Animal diseases
000 - Autres thèmes
U40 - Surveying methods

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Elanga Emmanuel, IRD (FRA)
  • Doucoure Souleymane, IRD (FRA)
  • Damien Georgia, IRD (BEN)
  • Mouchet François, IRD (FRA)
  • Drame Papa Makhtar, IRD (FRA)
  • Cornelie Sylvie, IRD (BEN)
  • Noukpo Herbert, IRD (BEN)
  • Yamadjako Sandra, IRD (BEN)
  • Djènontin Armel, IRD (BEN)
  • Moiroux Nicolas, CIRAD-BIOS-UMR CMAEE (BEN)
  • Missé Dorothée, IRD (FRA)
  • Akogbeto Martin, CREC [Centre de recherche entomologique de Cotonou] (BEN)
  • Corbel Vincent, IRD (BEN)
  • Henry Marie-Claire, IRD (BEN)
  • Chandre Fabrice, IRD (FRA)
  • Baldet Thierry, CIRAD-BIOS-UMR CMAEE (FRA) ORCID: 0000-0003-2979-9517
  • Remoue Franck, IRD (BEN)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/569017/)

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