Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis

Berri Fatima, Rimmelzwaan Guus F., Hanss Michel, Albina Emmanuel, Foucault-Grunenwald Marie-Laure, Lê Vuong B., Vogelzang-van Trierum Stella E., Gil Patricia, Camerer Eric, Martinez Dominique, Lina Bruno, Lijnen Roger, Carmeliet Peter, Riteau Béatrice. 2013. Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis. PLoS Pathogens, 9 (3):e100322, 12 p.

Quartile : Outlier, Sujet : PARASITOLOGY / Quartile : Outlier, Sujet : VIROLOGY / Quartile : Outlier, Sujet : MICROBIOLOGY

Résumé : Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen controls lung inflammation and pathogenesis of infections with influenza A/PR/8/34, highly pathogenic H5N1 and 2009 pandemic H1N1 viruses. Reduction of virus replication was not responsible for the observed effect. However, pharmacological depletion of fibrinogen, the main target of plasminogen reversed disease resistance of plasminogen-deficient mice or mice treated with an inhibitor of plasminogen-mediated fibrinolysis. Therefore, plasminogen contributes to the deleterious inflammation of the lungs and local fibrin clot formation may be implicated in host defense against influenza virus infections. Our studies suggest that the hemostatic system might be explored for novel treatments against influenza.

Mots-clés Agrovoc : Influenzavirus aviaire, infection, pathogénèse, inflammation, poumon, fibrinogène, coagulation sanguine, expérimentation en laboratoire, souris

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Berri Fatima, UCLB (FRA)
• Rimmelzwaan Guus F., Erasmus University Rotterdam (NLD)
• Hanss Michel, Hospices Civils de Lyon (FRA)
• Albina Emmanuel, CIRAD-BIOS-UMR CMAEE (GLP)
• Foucault-Grunenwald Marie-Laure, UCLB (FRA)
• Lê Vuong B., UCLB (FRA)
• Vogelzang-van Trierum Stella E., Erasmus University Rotterdam (NLD)
• Gil Patricia, CIRAD-BIOS-UMR CMAEE (FRA)
• Camerer Eric, INSERM (FRA)
• Martinez Dominique, CIRAD-DGDRD-DRAG (GLP)
• Lina Bruno, UCLB (FRA)
• Lijnen Roger, KUL (BEL)
• Carmeliet Peter, Vesalius Research Center (BEL)
• Riteau Béatrice, UCLB (FRA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/569184/)

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