A fatal neuroinvasive west nile virus infection in a traveler returning from Madagascar: Clinical, epidemiological and veterinary investigations

Larrieu Sophie, Cardinale Eric, Ocquidant Philippe, Roger Matthieu, Lepec Richard, Delatte Hélène, Camuset Guillaume, Despres Philippe, Brottet Elise, Charlin Cyril, Michault Alain. 2013. A fatal neuroinvasive west nile virus infection in a traveler returning from Madagascar: Clinical, epidemiological and veterinary investigations. American Journal of Tropical Medicine and Hygiene, 89 (2) : pp. 211-213.

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Abstract : A 58-year-old woman living in Reunion Island and returning from Madagascar was hospitalized for neuroinvasive encephalitis and died 1 month later. West Nile virus (WNV) infection was biologically confirmed by detection of immunoglobulin M (IgM) reactive with WNV antigens in both cerebrospinal fluid and serum, and weak neutralizing activity was also detected. A veterinary survey performed in her traveling area showed a seroprevalence of WNV of 28.7% (95% confidence interval [CI] = 21.1-36.3) in adult poultry, confirming an active circulation of the virus. Development of a severe form could be related to a weak antibody response, because the patient presented low IgM and IgG titers. This case report underlines the constant risk of emergence of West Nile in Indian Ocean territories, including Reunion Island where competent vectors are widely present during the whole year. (Résumé d'auteur)

Mots-clés Agrovoc : Encéphalite, Flavivirus, Genre humain, Mortalité, Transmission des maladies, Épidémiologie, Maladie de l'homme, Étude de cas

Mots-clés géographiques Agrovoc : Madagascar, Réunion

Mots-clés complémentaires : Fièvre du Nil occidental, Émergence

Classification Agris : L73 - Animal diseases
000 - Autres thèmes

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Larrieu Sophie, CIRE OI (REU)
  • Cardinale Eric, CIRAD-BIOS-UMR CMAEE (REU) ORCID: 0000-0002-3434-3541
  • Ocquidant Philippe, Groupe Hospitalier Sud Réunion (REU)
  • Roger Matthieu
  • Lepec Richard, COI [Commission de l'Océan Indien] (MUS)
  • Delatte Hélène, CIRAD-BIOS-UMR PVBMT (REU)
  • Camuset Guillaume, Groupe Hospitalier Sud Réunion (REU)
  • Despres Philippe, Institut Pasteur (FRA)
  • Brottet Elise, CIRE OI (REU)
  • Charlin Cyril, Groupe Hospitalier Sud Réunion (REU)
  • Michault Alain, Groupe Hospitalier Sud Réunion (REU)

Source : Cirad - Agritrop (

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