Nizamani Zaheer Ahmed, Holz Carine, Keita Djénéba, Libeau Geneviève, Albina Emmanuel, Servan de Almeida Renata. 2013. RNA interference as antiviral therapy: Dream or reality?. Virus Reviews and Research, 18 (1-2), 16 p.
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Résumé : Soon aft er discovery of RNA interference (RNAi), its potential as eff ective antiviral therapy was recognized. Since then RNAi has been variously exploited for antiviral purposes which could eff ectively block viral replication in vitro. For invivo use, however, delivery issue, toxicity, RNAi suppression and viral escape are still major hurdles. Here, we providean overview of the RNAi strategy and review the approaches that have been developed to surpass the obstacles and to achieve targeted gene silencing for antiviral and other therapies.
Classification Agris : L73 - Maladies des animaux
Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes
Auteurs et affiliations
- Nizamani Zaheer Ahmed, Sindh Agricultural University (PAK)
- Holz Carine, INRA (FRA)
- Keita Djénéba, INRA (FRA)
- Libeau Geneviève, CIRAD-BIOS-UMR CMAEE (FRA)
- Albina Emmanuel, CIRAD-BIOS-UMR CMAEE (GLP)
- Servan de Almeida Renata, CIRAD-BIOS-UMR CMAEE (FRA)
Source : Cirad - Agritrop (https://agritrop.cirad.fr/572735/)
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