Host-parasite network structure is associated with community-level immunogenetic diversity

Pilosof Shai, Fortuna Miguel A., Cosson Jean François, Galan Maxime, Chaisiri Kittipong, Ribas Alexis, Segal Eran, Krasnov Boris R., Morand Serge, Bascompte Jordi. 2014. Host-parasite network structure is associated with community-level immunogenetic diversity. Nature Communications, 5 (5172), 9 p.

Quartile : Outlier, Sujet : MULTIDISCIPLINARY SCIENCES

Résumé : Genes of the major histocompatibility complex (MHC) encode proteins that recognize foreign antigens and are thus crucial for immune response. In a population of a single host species, parasite-mediated selection drives MHC allelic diversity. However, in a community-wide context, species interactions may modulate selection regimes because the prevalence of a given parasite in a given host may depend on its prevalence in other hosts. By combining network analysis with immunogenetics, we show that host species infected by similar parasites harbour similar alleles with similar frequencies. We further show, using a Bayesian approach, that the probability of mutual occurrence of a functional allele and a parasite in a given host individual is nonrandom and depends on other host-parasite interactions, driving co-evolution within subgroups of parasite species and functional alleles. Therefore, indirect effects among hosts and parasites can shape host MHC diversity, scaling it from the population to the community level.

Mots-clés Agrovoc : relation hôte parasite, interactions biologiques, parasitologie, modèle mathématique, variation génétique, génétique des populations, immunologie, génétique animale, Helminthe, rongeur

Mots-clés géographiques Agrovoc : Cambodge, Thaïlande

Classification Agris : L72 - Organismes nuisibles des animaux
U10 - Informatique, mathématiques et statistiques
L20 - Écologie animale

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

• Pilosof Shai, Ben Gurion University of the Negev (ISR)
• Fortuna Miguel A., Integrative Ecology Group (ESP)
• Cosson Jean François, INRA (FRA)
• Galan Maxime, INRA (FRA)
• Chaisiri Kittipong, Mahidol University (THA)
• Ribas Alexis, Udon Thani Rajabhat University (THA)
• Segal Eran, Weizmann Institute of Science (ISR)
• Krasnov Boris R., Ben-Gurion University of the Negev (ISR)
• Morand Serge, CIRAD-ES-UPR AGIRs (LAO) ORCID: 0000-0003-3986-7659
• Bascompte Jordi, Integrative Ecology Group (ESP)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/574136/)

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