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The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

Cociancich Stéphane, Pesic Alexander, Petras Daniel, Uhlmann Stefanie, Kretz Julian, Schubert Vivien, Vieweg Laura, Duplan Sandrine, Marguerettaz Mélanie, Noëll Julie, Pieretti Isabelle, Hügelland Manuela, Kemper Sebastien, Mainz Andi, Rott Philippe, Royer Monique, Süssmuth Roderich. 2015. The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine. Nature Chemical Biology, 11 : pp. 195-197.

Journal article ; Article de revue à facteur d'impact
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Quartile : Outlier, Sujet : BIOCHEMISTRY & MOLECULAR BIOLOGY

Abstract : Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug. (Résumé d'auteur)

Mots-clés Agrovoc : Toxine bactérienne, Xanthomonas albilineans, Structure chimique, Biosynthèse, Bactéricide, Saccharum officinarum

Mots-clés complémentaires : Albicidine

Classification Agris : 000 - Other themes
H20 - Plant diseases

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Cociancich Stéphane, CIRAD-BIOS-UMR BGPI (FRA)
  • Pesic Alexander, Technische Universitaet Berlin (DEU)
  • Petras Daniel, Technische Universitaet Berlin (DEU)
  • Uhlmann Stefanie, Technische Universitaet Berlin (DEU)
  • Kretz Julian, Technische Universitaet Berlin (DEU)
  • Schubert Vivien, Technische Universitaet Berlin (DEU)
  • Vieweg Laura, Technische Universitaet Berlin (DEU)
  • Duplan Sandrine, CIRAD-BIOS-UMR BGPI (FRA)
  • Marguerettaz Mélanie
  • Noëll Julie, CIRAD-BIOS-UMR BGPI (FRA)
  • Pieretti Isabelle, CIRAD-BIOS-UMR BGPI (FRA)
  • Hügelland Manuela, Technische Universitaet Berlin (DEU)
  • Kemper Sebastien, Technische Universitaet Berlin (DEU)
  • Mainz Andi, Technische Universitaet Berlin (DEU)
  • Rott Philippe, CIRAD-BIOS-UMR BGPI (USA) ORCID: 0000-0001-6085-6159
  • Royer Monique, CIRAD-BIOS-UMR BGPI (FRA)
  • Süssmuth Roderich, Technische Universitaet Berlin (DEU)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/575585/)

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