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Binding sites of mirnas with transcription factors' genes of Camelus ferus

Alybaeva Aigul, Berillo O., Niyazova R., Faye Bernard, Ivashchenko Anatoly. 2015. Binding sites of mirnas with transcription factors' genes of Camelus ferus. Veterinariâ, 42 (2), n.spéc. Silk road camel: The camelids, main stake for sustainable development : pp. 340-342. 4th Conference of the International Society of Camelid Research and Development/ISOCARD 2015. 4, Almaty, Kazakhstan, 8 June 2015/12 June 2015.

Journal article ; Article de revue sans comité de lecture
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Titre kazakh : [Titre en Kazakh] / Titre russe : [Titre en Russe]

Additional Information : Résumés disponibles en Kazakh et en Russe

Abstract : We searched binding sites of miRNAs in mRNAs of 157 transcription factors' genes of wild camel (Camelus ferus). The mRNAs of 96 genes of zincfinger transcription factors' family have 16, 210 and 34 binding sites in the 5'UTRs, CDSs and 3'UTRs, respectively. The mRNA of GLI2 gene has binding sites for eight miRNAs. The mRNAs of GLIS1 and ZNF236 genes contain seven binding sites. In the 3'UTR mRNA of ZFP91 gene were revealed 13 miR-574-5p binding sites arranged located through two nucleotides. The ΔG/ΔGm value is equal to 93%. miR-1322 has one binding site in GLI1, HINFP, HIVEP1, MTF1, SALL4, SP1, ZNF335 and ZNF451 genes, two sites in ZNF142, three sites in EGR1 gene. mRNA of VEZF1 gene has eight miR-1322 binding sites arranged located through three nucleotides. miRNAs with the length of 25 and 26 nucleotides have the highest binding energy. The ΔG value varied from -114,6 kJ/mole to -138,0 kJ/mole. Some miRNAs with a length of 23 and 24 nucleotides also have a high value ΔG varied from -112,5 kJ/mole to -129,5 kJ/mole. The results show a strong interaction between the expression of genes of transcription factors and miRNAs. (Résumé d'auteur)

Mots-clés Agrovoc : Camelus, Animal sauvage, Transcription génique, ARN, Facteur de transcription, Expression des gènes, Genre humain

Mots-clés complémentaires : Camelus ferus

Classification Agris : L10 - Animal genetics and breeding

Champ stratégique Cirad : Axe 1 (2014-2018) - Agriculture écologiquement intensive

Auteurs et affiliations

  • Alybaeva Aigul, CIRAD-ES-UMR SELMET (FRA)
  • Berillo O., Al-Farabi Kazakh National University (KAZ)
  • Niyazova R., Al-Farabi Kazakh National University (KAZ)
  • Faye Bernard, CIRAD-ES-UMR SELMET (SAU)
  • Ivashchenko Anatoly, Al-Farabi Kazakh National University (KAZ)

Autres liens de la publication

Source : Cirad-Agritrop (https://agritrop.cirad.fr/577415/)

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