Tolerance to trypanosomatids: A threat, or a key for disease elimination?

Berthier David, Brenière Simone Frédérique, Bras-Gonçalves Rachel, Lemesre Jean-Loup, Jamonneau Vincent, Solano Philippe, Lejon Veerle, Thevenon Sophie, Bucheton Bruno. 2016. Tolerance to trypanosomatids: A threat, or a key for disease elimination?. Trends in Parasitology, 32 (2) : 157-168.

https://doi.org/10.1016/j.pt.2015.11.001

Article de revue ; Article de synthèse ; Article de revue à facteur d'impact

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Quartile : Outlier, Sujet : PARASITOLOGY

Résumé : So far, research on trypanosomatid infections has been driven by 'disease by disease' approaches, leading to different concepts and control strategies. It is, however, increasingly clear that they share common features such as the ability to generate long-lasting asymptomatic infections in their mammalian hosts. Trypanotolerance, long integrated in animal African trypanosomiasis control, historically refers to the ability of cattle breeds to limit Trypanosoma infection and pathology, but has only recently been recognized in humans. Whilst trypanotolerance is absent from the vocabulary on leishmaniasis and Chagas disease, asymptomatic infections also occur. We review the concept of trypanotolerance across the trypanosomatids and discuss the importance of asymptomatic carriage in the current context of elimination.

Mots-clés Agrovoc : trypanosomose, trypanosomose africaine, Trypanosoma, Leishmania, tolérance, résistance aux maladies, résistance génétique, éradication des maladies, contrôle de maladies, bovin, mammifère, genre humain, Trypanosoma brucei