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Surveillance of dengue and chikungunya infection in Dong Thap, Vietnam: A 13-month study

Lien Pham Thi Kim, Briant Laurence, Tang Truong Ba, Trang Bui Minh, Gavotte Laurent, Cornillot Emmanuel, Duoc Vu Trong, Duong Tran Nhu, Frutos Roger, Nga Phan Thi. 2016. Surveillance of dengue and chikungunya infection in Dong Thap, Vietnam: A 13-month study. Asian Pacific Journal of Tropical Medicine, 9 (1) : pp. 39-43.

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Quartile : Q3, Sujet : TROPICAL MEDICINE / Quartile : Q4, Sujet : PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH (Science)

Abstract : Objective To establish a surveillance in Dong Thap, at the border with Cambodia by assessing the presence of DENV serotypes and CHIKV among patients hospitalized at Dong Thap general hospital. Methods Cross-sectional descriptive analysis was conducted on a cohort of 131 patients hospitalized with acute fever and symptoms compatible with dengue or chikungunya. The study was conducted from January 2012 to February 2013. The full clinical picture was established as well as serological and molecular detection. Serological analysis was sequentially performed on blood samples collected on admission and an average of seven days after admission. The detection of IgM antibody to DENV was performed by IgM capture ELISA and the detection of DENV and CHIKV RNA was done by reverse-transcription multiplex PCR. Results 101 patients out of 131 (77%) were confirmed with dengue. All four dengue serotypes were detected with a predominance of DENV2 and DENV4. No chikungunya infection was detected although reported in neighboring Cambodia. A differential efficiency of serological dengue detection was observed. Efficiency was 29% upon admission and 53% after seven days on the same patients. 30 patients out of 131 (23%) were negative with both DENV and CHIKV. Conclusions Dengue is at risk of being underestimated and chikungunya is not systematically detected. Changes in detection and surveillance procedures are therefore discussed to increase efficiency of dengue detection and continue the monitoring the emergence of CHIKV in Dong Thap province and in Vietnam. (Résumé d'auteur)

Mots-clés Agrovoc : Virose, Maladie de l'homme, Surveillance épidémiologique, Sérologie, Identification, Enquête pathologique, Virus de chikungunya, Flavivirus

Mots-clés géographiques Agrovoc : Viet Nam, Cambodge

Mots-clés complémentaires : Virus de la dengue

Classification Agris : L73 - Animal diseases
L70 - Veterinary science and hygiene - General aspects
000 - Other themes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Lien Pham Thi Kim, NIHE (VNM)
  • Briant Laurence, Université de Montpellier (FRA)
  • Tang Truong Ba, Dong Thap General Hospital (VNM)
  • Trang Bui Minh, NIHE (VNM)
  • Gavotte Laurent, UM2 (FRA)
  • Cornillot Emmanuel, Institut de Biologie Computationnelle (FRA)
  • Duoc Vu Trong, NIHE (VNM)
  • Duong Tran Nhu, NIHE (VNM)
  • Frutos Roger, CIRAD-BIOS-UMR INTERTRYP (FRA)
  • Nga Phan Thi, NIHE (VNM)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/579763/)

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