Circadian clock-related genetic risk scores and risk of placental abruption

Qiu Chunfang, Gelaye Bizu, Denis Marie, Tadesse Mahlet G., Luque Fernandez Miguel Angel, Enquobahrie Daniel A., Ananth Cande V., Sanchez Sixto E., Williams Michelle A.. 2015. Circadian clock-related genetic risk scores and risk of placental abruption. Placenta, 36 (12) : pp. 1480-1486.

Journal article ; Article de recherche ; Article de revue à facteur d'impact
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Quartile : Q1, Sujet : OBSTETRICS & GYNECOLOGY / Quartile : Q2, Sujet : REPRODUCTIVE BIOLOGY / Quartile : Q2, Sujet : DEVELOPMENTAL BIOLOGY

Abstract : Introduction The circadian clock plays an important role in several aspects of female reproductive biology. Evidence linking circadian clock-related genes to pregnancy outcomes has been inconsistent. We sought to examine whether variations in single nucleotide polymorphisms (SNPs) of circadian clock genes are associated with PA risk. Methods Maternal blood samples were collected from 470 PA case and 473 controls. Genotyping was performed using the Illumina Cardio-MetaboChip platform. We examined 119 SNPs in 13 candidate genes known to control circadian rhythms (e.g., CRY2, ARNTL, and RORA). Univariate and penalized logistic regression models were fit to estimate odds ratios (ORs); and the combined effect of multiple SNPs on PA risk was estimated using a weighted genetic risk score (wGRS). Results A common SNP in the RORA gene (rs2899663) was associated with a 21% reduced odds of PA (P < 0.05). The odds of PA increased with increasing wGRS (Ptrend < 0.001). The corresponding ORs were 1.00, 1.83, 2.81 and 5.13 across wGRS quartiles. Participants in the highest wGRS quartile had a 5.13-fold (95% confidence interval: 3.21–8.21) higher odds of PA compared to those in the lowest quartile. Although the test for interaction was not significant, the odds of PA was substantially elevated for preeclamptics with the highest wGRS quartile (OR = 14.44, 95%CI: 6.62–31.53) compared to normotensive women in the lowest wGRS quartile. Discussion Genetic variants in circadian rhythm genes may be associated with PA risk. Larger studies are needed to corroborate these findings and to further elucidate the pathogenesis of this important obstetrical complication. (Résumé d'auteur)

Mots-clés Agrovoc : Femme, Placenta, Facteur de risque, Rythme circadien, Danger pour la santé, Génétique, Polymorphisme génétique, Variation génétique, Génotype, Parturition, Maladie de l'appareil génital fém, Épidémiologie

Mots-clés géographiques Agrovoc : Pérou

Mots-clés complémentaires : Rupture

Mots-clés libres : Genetic risk score, Placental abruption, SNPs

Classification Agris : 000 - Other themes
L53 - Animal physiology - Reproduction
L10 - Animal genetics and breeding
L74 - Miscellaneous animal disorders

Champ stratégique Cirad : Hors axes (2014-2018)

Auteurs et affiliations

  • Qiu Chunfang, Swedish Medical Center (USA)
  • Gelaye Bizu, Havard University (USA)
  • Denis Marie, CIRAD-BIOS-UMR AGAP (FRA)
  • Tadesse Mahlet G., Georgetown University (USA)
  • Luque Fernandez Miguel Angel, Havard University (USA)
  • Enquobahrie Daniel A., University of Washington (USA)
  • Ananth Cande V., Columbia University (USA)
  • Sanchez Sixto E., Columbia University (USA)
  • Williams Michelle A., Havard University (USA)

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