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Escaping deleterious immune response in their hosts: Lessons from trypanosomatids

Geiger Anne, Bossard Géraldine, Sereno Denis, Pissarra Joana, Lemesre Jean-Loup, Vincendeau Philippe, Holzmuller Philippe. 2016. Escaping deleterious immune response in their hosts: Lessons from trypanosomatids. Frontiers in Immunology, 7:212, 21 p.

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Quartile : Q1, Sujet : IMMUNOLOGY

Abstract : The Trypanosomatidae family includes the genera Trypanosoma and Leishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector. Trypanosoma brucei gambiense, Trypanosoma cruzi, and Leishmania spp. are important human pathogens causing human African trypanosomiasis (HAT or sleeping sickness), Chagas' disease, and various clinical forms of Leishmaniasis, respectively. They are transmitted to humans by tsetse flies, triatomine bugs, or sandflies, and affect millions of people worldwide. In humans, extracellular African trypanosomes (T. brucei) evade the hosts' immune defenses, allowing their transmission to the next host, via the tsetse vector. By contrast, T. cruzi and Leishmania sp. have developed a complex intracellular lifestyle, also preventing several mechanisms to circumvent the host's immune response. This review seeks to set out the immune evasion strategies developed by the different trypanosomatids resulting from parasite–host interactions and will focus on: clinical and epidemiological importance of diseases; life cycles: parasites–hosts–vectors; innate immunity: key steps for trypanosomatids in invading hosts; deregulation of antigen-presenting cells; disruption of efficient specific immunity; and the immune responses used for parasite proliferation. (Résumé d'auteur)

Mots-clés Agrovoc : Trypanosoma, Leishmania, Trypanosoma cruzi, Trypanosoma brucei, Relation hôte parasite, Transmission des maladies, Interactions biologiques, Immunodépression, Hôte, Cycle de développement, Immunité, Réponse immunitaire, famille (taxon), Vecteur de maladie, Maladie de l'homme, Maladie des animaux, Immunologie, Parasitisme, Insecta, Vertebrata [EN]

Mots-clés complémentaires : Trypanosomatidae

Mots-clés libres : Trypanosomatidae family, Parasite–host interactions, Immunosuppression, Leishmania sp., Trypanosoma brucei sp., Trypanosoma cruzi

Classification Agris : L72 - Pests of animals
L73 - Animal diseases
000 - Autres thèmes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Geiger Anne, IRD (FRA)
  • Bossard Géraldine, CIRAD-BIOS-UMR INTERTRYP (FRA)
  • Sereno Denis, IRD (FRA)
  • Pissarra Joana, IRD (FRA)
  • Lemesre Jean-Loup, IRD (FRA)
  • Vincendeau Philippe, Université de Bordeaux II (FRA)
  • Holzmuller Philippe, CIRAD-BIOS-UMR CMAEE (FRA) ORCID: 0000-0002-8919-9081

Source : Cirad-Agritrop (https://agritrop.cirad.fr/580644/)

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