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Endophytic actinobacteria associated with Dracaena cochinchinensis Lour.: Isolation, diversity and their cytotoxic activities

Salam Nimaichand, Khieu Thi Nhan, Liu Min-Jiao, Vu Thu Trang, Chu-Ky Son, Quach Ngoc-Tung, Phi Quyet Tien, Manik Prabhu Narsing Rao, Fontana Angélique, Sarter Samira, Li Wen Jun. 2017. Endophytic actinobacteria associated with Dracaena cochinchinensis Lour.: Isolation, diversity and their cytotoxic activities. BioMed Research International, 2017 (1308563), 11 p.

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Quartile : Q2, Sujet : BIOTECHNOLOGY & APPLIED MICROBIOLOGY / Quartile : Q3, Sujet : MEDICINE, RESEARCH & EXPERIMENTAL

Résumé : Dracaena cochinchinensis Lour. is an ethnomedicinally important plant used in traditional Chinese medicine known as dragon's blood. Excessive utilization of the plant for extraction of dragon's blood had resulted in the destruction of the important niche. During a study to provide a sustainable way of utilizing the resources, the endophytic Actinobacteria associated with the plant were explored for potential utilization of their medicinal properties. Three hundred and four endophytic Actinobacteria belonging to the genera Streptomyces, Nocardiopsis, Brevibacterium, Microbacterium, Tsukamurella, Arthrobacter, Brachybacterium, Nocardia, Rhodococcus, Kocuria, Nocardioides, and Pseudonocardia were isolated from different tissues of D. cochinchinensis Lour. Of these, 17 strains having antimicrobial and anthracyclines-producing activities were further selected for screening of antifungal and cytotoxic activities against two human cancer cell lines, MCF-7 and Hep G2. Ten of these selected endophytic Actinobacteria showed antifungal activities against at least one of the fungal pathogens, of which three strains exhibited cytotoxic activities with IC50-values ranging between 3 and 33 μg·mL−1. Frequencies for the presence of biosynthetic genes, polyketide synthase- (PKS-) I, PKS-II, and nonribosomal peptide synthetase (NRPS) among these 17 selected bioactive Actinobacteria were 29.4%, 70.6%, and 23.5%, respectively. The results indicated that the medicinal plant D. cochinchinensis Lour. is a good niche of biologically important metabolites-producing Actinobacteria.

Mots-clés Agrovoc : endophyte, plante médicinale, Streptomyces, Dracaena, propriété antimicrobienne

Mots-clés libres : Endophytic actinobacteria, Dracaena cochinchinensis Lour., Antifungal activity, Cytotoxic activities

Classification Agris : 000 - Autres thèmes
F01 - Culture des plantes

Champ stratégique Cirad : Axe 2 (2014-2018) - Valorisation de la biomasse

Auteurs et affiliations

  • Salam Nimaichand, Sun Yat-Sen University (CHN)
  • Khieu Thi Nhan, Sun Yat-Sen University (CHN)
  • Liu Min-Jiao, Yunnan University (CHN)
  • Vu Thu Trang, HUST (VNM)
  • Chu-Ky Son, CIRAD-PERSYST-UMR Qualisud (FRA)
  • Quach Ngoc-Tung, VAST (VNM)
  • Phi Quyet Tien, VAST (VNM)
  • Manik Prabhu Narsing Rao, Sun Yat-Sen University (CHN)
  • Fontana Angélique, UM2 (FRA)
  • Sarter Samira, CIRAD-PERSYST-UMR ISEM (FRA)
  • Li Wen Jun, Yunnan University (CHN)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/584007/)

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