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Old Plasmodium DNA from Spain hints at parasite origins

Aranda Carles, Gelabert Pere, Sandoval-Velasco Marcela, Olalde Iñigo, Fregel Rosa, Rieux Adrien, Escosa Raül, Paaijmans Krijn, Mueller Ivo, Gilbert Thomas, Lalueza-Fox Carles. 2017. Old Plasmodium DNA from Spain hints at parasite origins. In : Sove 2017 New technology conquering old vectors?. Miranda Chueca (ed.), Miguel Ángel (ed.), Alten, Bulent (ed.). Palma de Mallorque : SOVE, Résumé, p. 84. ISBN 978-84-697-6086-4 International SOVE congress: New technology conquering old vectors?. 7, Palma de Mallorque, Espagne, 1 October 2017/7 October 2017.

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Abstract : After the certification of eradication of malaria in Spain in 1964, and in southern Europe in the mid-20th century, several studies focused on the capacity of the former malaria vector Anopheles atroparvus, still present in the region, to transmit different malaria parasites, mainly Plasmodium vivax and Plasmodium falciparum. A strain of An. atroparvus from Ebro delta in Tarragona was isolated and maintained and tests were carried out to determine its sensibility to P. falciparum, showing no infectivity. In 2015, a set of slides with blood stains of malaria-affected people from the Ebro delta, dated between 1942-1944, were recovered in a local medical collection. DNA was extracted from the slides, a subset stained with Giemsa and another consisting of dried blood spots; data was generated using Illumina sequencing. P. vivax and P. falciparum mitochondrial genome sequences were subsequently reconstructed from the resulting data. Phylogenetic analysis of the eradicated European P. vivax mtDNA genome indicates that the European isolate is closely related to the most common present-day American haplotype and likely entered the American continent post-Columbian contact. Furthermore, the European P. falciparum mtDNA indicates a link with current Indian strains that is in agreement with historical accounts. Present and future results will give light on the interaction vector parasite and supports that present Plasmodium distribution is a result of a series of human mediated dispersals involving transport between different continents. (Texte integral)

Classification Agris : L72 - Pests of animals
L73 - Animal diseases
000 - Autres thèmes

Auteurs et affiliations

  • Aranda Carles, Servei de Control de Mosquits (ESP)
  • Gelabert Pere, Institute of Evolutionary Biology (ESP)
  • Sandoval-Velasco Marcela, Natural History Museum (DNK)
  • Olalde Iñigo, Institute of Evolutionary Biology (ESP)
  • Fregel Rosa, Stanford University (USA)
  • Rieux Adrien, CIRAD-BIOS-UMR PVBMT (REU)
  • Escosa Raül, Consorci de Polítiques Ambientals de les Terres de l'Ebre (ESP)
  • Paaijmans Krijn, Barcelona Institute for Global Health (ESP)
  • Mueller Ivo, Barcelona Institute for Global Health (ESP)
  • Gilbert Thomas, Natural History Museum (DNK)
  • Lalueza-Fox Carles, Institute of Evolutionary Biology (ESP)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/585772/)

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