Agritrop
Accueil

Approaches and perspectives for development of african swine fever virus vaccines

Arias Marisa, De la Torre Ana, Dixon Linda, Gallardo Carmina, Jori Ferran, Laddomada Alberto, Martins Carlos, Parkhouse R. Michael, Revilla Yolanda, Rodriguez Fernando, Sanchez Vizcaino José Manuel. 2017. Approaches and perspectives for development of african swine fever virus vaccines. Vaccines, 5 (4):e35, 20 p.

Article de revue ; Article de synthèse ; Article de revue à facteur d'impact Revue en libre accès total
[img]
Prévisualisation
Version publiée - Anglais
Utilisation soumise à autorisation de l'auteur ou du Cirad.
vaccines-05-00035-v2.pdf

Télécharger (763kB) | Prévisualisation

Résumé : African swine fever (ASF) is a complex disease of swine, caused by a large DNA virus belonging to the family Asfarviridae. The disease shows variable clinical signs, with high case fatality rates, up to 100%, in the acute forms. ASF is currently present in Africa and Europe where it circulates in different scenarios causing a high socio-economic impact. In most affected regions, control has not been effective in part due to lack of a vaccine. The availability of an effective and safe ASFV vaccines would support and enforce control–eradication strategies. Therefore, work leading to the rational development of protective ASF vaccines is a high priority. Several factors have hindered vaccine development, including the complexity of the ASF virus particle and the large number of proteins encoded by its genome. Many of these virus proteins inhibit the host's immune system thus facilitating virus replication and persistence. We review previous work aimed at understanding ASFV–host interactions, including mechanisms of protective immunity, and approaches for vaccine development. These include live attenuated vaccines, and “subunit” vaccines, based on DNA, proteins, or virus vectors. In the shorter to medium term, live attenuated vaccines are the most promising and best positioned candidates. Gaps and future research directions are evaluated.

Mots-clés Agrovoc : virus peste porcine africaine, peste porcine africaine, maladie des animaux, vaccination, immunologie, vaccin, virulence

Mots-clés libres : African swine fever, Vaccine, Immunology, Vaccine gaps

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Agences de financement européennes : European Commission

Auteurs et affiliations

  • Arias Marisa, INIA [Espagne] (ESP)
  • De la Torre Ana, INIA [Espagne] (ESP)
  • Dixon Linda, The Pirbright Institute (GBR)
  • Gallardo Carmina, CISA (ESP)
  • Jori Ferran, CIRAD-BIOS-UMR ASTRE (FRA) ORCID: 0000-0001-5451-7767
  • Laddomada Alberto, IZSS (ITA)
  • Martins Carlos, Universidade Técnica de Lisboa (PRT)
  • Parkhouse R. Michael, IGC (PRT)
  • Revilla Yolanda, CBMSO (ESP)
  • Rodriguez Fernando, IRTA (ESP)
  • Sanchez Vizcaino José Manuel, Universidad Complutense de Madrid (ESP)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/585856/)

Voir la notice (accès réservé à Agritrop) Voir la notice (accès réservé à Agritrop)

[ Page générée et mise en cache le 2024-03-19 ]