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The global distribution and spread of the mobilized colistin resistance gene mcr-1

Wang Ruobing, van Dorp Lucy, Shaw Liam P., Bradley Phelim, Wang Qi, Wang Xiaojuan, Jin Longyang, Zhang Qing, Liu Yuqing, Rieux Adrien, Dorai-Schneiders Thamarai, Weinert Lucy Anne, Iqbal Zamin, Didelot Xavier, Wang Hui, Balloux François. 2018. The global distribution and spread of the mobilized colistin resistance gene mcr-1. Nature Communications, 9 (1):1179, 9 p.

Journal article ; Article de revue à facteur d'impact
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Quartile : Outlier, Sujet : MULTIDISCIPLINARY SCIENCES

Abstract : Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.

Mots-clés Agrovoc : Enterobacteriaceae, Infection, Résistance aux antibiotiques, Colistine, Génétique, Santé publique, Maladie de l'homme

Classification Agris : 000 - Other themes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Wang Ruobing, Peking University People's Hospital (CHN)
  • van Dorp Lucy, University College London (GBR)
  • Shaw Liam P., University College London (GBR)
  • Bradley Phelim, University of Oxford (GBR)
  • Wang Qi, Peking University People's Hospital (CHN)
  • Wang Xiaojuan, Peking University People's Hospital (CHN)
  • Jin Longyang, Peking University People's Hospital (CHN)
  • Zhang Qing, Shandong Academy of Agricultural Sciences (CHN)
  • Liu Yuqing, Shandong Academy of Agricultural Sciences (CHN)
  • Rieux Adrien, CIRAD-BIOS-UMR PVBMT (REU)
  • Dorai-Schneiders Thamarai, Division of Infection and Pathway Medicine (GBR)
  • Weinert Lucy Anne, Department of Veterinary Medicine (GBR)
  • Iqbal Zamin, University of Oxford (GBR)
  • Didelot Xavier, Imperial College London (GBR)
  • Wang Hui, Peking University People's Hospital (CHN)
  • Balloux François, University College London (GBR) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/587607/)

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