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Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia

Wongprompitak Patimaporn, Duong Veasna, Anukool Wichittra, Sreyrath Lay, Mai Trinh Thi Xuan, Gavotte Laurent, Moulia Catherine, Cornillot Emmanuel, Ekpo Pattama, Suputtamongkol Yupin, Buchy Philippe, Frutos Roger. 2015. Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia. Infection, Genetics and Evolution, 31 : pp. 1-8.

Journal article ; Article de recherche ; Article de revue à facteur d'impact
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Quartile : Q2, Sujet : INFECTIOUS DISEASES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie

Abstract : Orientia tsutsugamushi is the causative agent of scrub typhus, a major cause of febrile illness in rural area of Asia–Pacific region. A multi-locus sequence typing (MLST) analysis was performed on strains isolated from human patients from 3 countries in Southeast Asia: Cambodia, Vietnam and Thailand. The phylogeny of the 56-kDa protein encoding gene was analyzed on the same strains and showed a structured topology with genetically distinct clusters. MLST analysis did not lead to the same conclusion. DNA polymorphism and phylogeny of individual gene loci indicated a significant level of recombination and genetic diversity whereas the ST distribution indicated the presence of isolated patches. No correlation was found with the geographic origin. This work suggests that weak divergence in core genome and ancestral haplotypes are maintained by permanent recombination in mites while the 56-kDa protein gene is diverging in higher speed due to selection by the mammalian immune system.

Mots-clés Agrovoc : Rickettsiose, Fièvre, Acaridae, Leptotrombidium, Virus, Génome

Mots-clés géographiques Agrovoc : Asie du Sud-Est, Cambodge, Viet Nam, Thaïlande

Mots-clés complémentaires : Orientia tsutsugamushi, Typhus des broussailles, Fièvre fluviale du Japon

Classification Agris : L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Wongprompitak Patimaporn, Mahidol University (THA)
  • Duong Veasna, Institut Pasteur du Cambodge (KHM)
  • Anukool Wichittra, Mahidol University (THA)
  • Sreyrath Lay, Institut Pasteur du Cambodge (KHM)
  • Mai Trinh Thi Xuan, Institut Pasteur de Ngatrang (VNM)
  • Gavotte Laurent, UM2 (FRA)
  • Moulia Catherine, ISEM (FRA)
  • Cornillot Emmanuel, Institut de Biologie Computationnelle (FRA)
  • Ekpo Pattama, Mahidol University (THA)
  • Suputtamongkol Yupin, Mahidol University (THA)
  • Buchy Philippe, Institut Pasteur du Cambodge (KHM)
  • Frutos Roger, CIRAD-BIOS-UMR INTERTRYP (FRA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/591886/)

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