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In Vitro, in Vivo, and spectroscopic assessment of lead exposure reduction via ingestion and inhalation pathways following immobilization using phosphorus and iron amendments

Kastury Farzana, Smith Euan, Doelsch Emmanuel, Lombi Enzo, Donnelly Martin J., Cmielewski Patricia L., Parsons David W., Scheckel Kirk G., Paterson David, de Jonge Martin D., Herde Carina, Juhasz Albert L.. 2019. In Vitro, in Vivo, and spectroscopic assessment of lead exposure reduction via ingestion and inhalation pathways following immobilization using phosphorus and iron amendments. Environmental Science and Technology, 53 (17) : pp. 10329-10341.

Journal article ; Article de recherche ; Article de revue à facteur d'impact
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Url - jeu de données : https://figshare.com/articles/_i_In_Vitro_i_i_in_Vivo_i_and_Spectroscopic_Assessment_of_Lead_Exposure_Reduction_via_Ingestion_and_Inhalation_Pathways_Using_Phosphate_and_Iron_Amendments/9588935

Quartile : Outlier, Sujet : ENVIRONMENTAL SCIENCES / Quartile : Q1, Sujet : ENGINEERING, ENVIRONMENTAL

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Abstract : This study compared lead (Pb) immobilization efficacies in mining/smelting impacted soil using phosphate and iron amendments via ingestion and inhalation pathways using in vitro and in vivo assays, in conjunction with investigating the dynamics of dust particles in the lungs and gastro-intestinal tract via X-ray fluorescence (XRF) microscopy. Phosphate amendments [phosphoric acid (PA), hydroxyapatite, monoammonium phosphate (MAP), triple super phosphate (TSP), and bone meal biochar] and hematite were applied at a molar ratio of Pb:Fe/P = 1:5. Pb phosphate formation was investigated in the soil/post-in vitro bioaccessibility (IVBA) residuals and in mouse lung via extended X-ray absorption fine structure (EXAFS) and X-ray absorption near edge structures (XANES) spectroscopy, respectively. EXAFS analysis revealed that anglesite was the dominant phase in the ingestible (<250 μm) and inhalable (<10 μm) particle fractions. Pb IVBA was significantly reduced (p < 0.05) by phosphate amendments in the <250 μm fraction (solubility bioaccessibility research consortium assay) and by PA, MAP, and TSP in the <10 μm fraction (inhalation–ingestion bioaccessibility assay). A 21.1% reduction in Pb RBA (<250 μm fraction) and 56.4% reduction in blood Pb concentration (<10 μm fraction) were observed via the ingestion and inhalation pathways, respectively. XRF microscopy detected Pb in the stomach within 4 h, presumably via mucociliary clearance.

Mots-clés Agrovoc : Toxicité du sol, Santé publique

Classification Agris : 000 - Autres thèmes
T10 - Occupational diseases and hazards
P33 - Soil chemistry and physics

Champ stratégique Cirad : CTS 7 (2019-) - Hors champs stratégiques

Agence(s) de financement européenne(s) : European Commission

Programme de financement européen : H2020

Projet(s) de financement européen(s) : SPEciation and dynamiCs of TRace Elements

Auteurs et affiliations

  • Kastury Farzana, University of South Australia (AUS) - auteur correspondant
  • Smith Euan, University of South Australia (AUS)
  • Doelsch Emmanuel, CIRAD-PERSYST-UPR Recyclage et risque (FRA) ORCID: 0000-0002-7478-4296
  • Lombi Enzo, University of South Australia (AUS)
  • Donnelly Martin J., University of Adelaide (AUS)
  • Cmielewski Patricia L., University of Adelaide (AUS)
  • Parsons David W., University of Adelaide (AUS)
  • Scheckel Kirk G., United States Environmental Protection Agency (USA)
  • Paterson David, Australian Synchrotron (AUS)
  • de Jonge Martin D., Australian Synchrotron (AUS)
  • Herde Carina, South Australian Health and Medical Research Institute (AUS)
  • Juhasz Albert L., University of South Australia (AUS)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/593369/)

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