Nipah virus circulation at human–bat interfaces, Cambodia

Cappelle Julien, Hoem Thavry, Hul Vibol, Furey Neil M., Nguon Kunthy, Prigent Steven, Dupon Liane, Ken Sreymom, Neung Chhoeuth, Hok Visal, Pring Long, Lim Thona, Bumrungsri Sara, Duboz Raphaël, Buchy Philippe, Ly Sowath, Duong Veasna, Tarantola Arnaud, Binot Aurélie, Dussart Philippe. 2020. Nipah virus circulation at human–bat interfaces, Cambodia. Bulletin of the World Health Organization, 98 (8) : 539-547.

Url - éditeur : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411325/

Quartile : Outlier, Sujet : PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH (Science)

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Economie-gestion; Psychologie-éthologie-ergonomie

Résumé : Objective: To better understand the potential risks of Nipah virus emergence in Cambodia by studying different components of the interface between humans and bats.Methods: From 2012 to 2016, we conducted a study at two sites in Kandal and Battambang provinces where fruit bats (Pteropus lylei) roost. We combined research on: bat ecology (reproductive phenology, population dynamics and diet); human practices and perceptions (ethnographic research and a knowledge, attitude and practice study); and Nipah virus circulation in bat and human populations (virus monitoring in bat urine and anti-Nipah-virus antibody detection in human serum).Findings : Our results confirmed circulation of Nipah virus in fruit bats (28 of 3930 urine samples positive by polymerase chain reaction testing). We identified clear potential routes for virus transmission to humans through local practices, including fruit consumed by bats and harvested by humans when Nipah virus is circulating, and palm juice production. Nevertheless, in the serological survey of 418 potentially exposed people, none of them were seropositive to Nipah virus. Differences in agricultural practices among the regions where Nipah virus has emerged may explain the situation in Cambodia and point to actions to limit the risks of virus transmission to humans.Conclusion: Human practices are key to understanding transmission risks associated with emerging infectious diseases. Social science disciplines such as anthropology need to be integrated in health programmes targeting emerging infectious diseases. As bats are hosts of major zoonotic pathogens, such integrated studies would likely also help to reduce the risk of emergence of other bat-borne diseases.

Mots-clés Agrovoc : Paramyxoviridae, virus à ARN, Pteropus, Pteropodidae, écologie animale, écologie microbienne, urine, anticorps, épidémie, zoonose, Nipah henipavirus

Mots-clés géographiques Agrovoc : Cambodge

Mots-clés complémentaires : Henipavirus, Pteropus lylei, Émergence

Classification Agris : S50 - Santé humaine

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Agences de financement européennes : European Commission

Auteurs et affiliations

• Cappelle Julien, CIRAD-BIOS-UMR ASTRE (FRA) ORCID: 0000-0001-7668-1971 - auteur correspondant
• Hoem Thavry, Institut Pasteur du Cambodge (KHM)
• Hul Vibol, Institut Pasteur du Cambodge (KHM)
• Furey Neil M., Fauna and Flora International (KHM)
• Nguon Kunthy, Institut Pasteur du Cambodge (KHM)
• Prigent Steven, CNRS (FRA)
• Dupon Liane, INRAE (FRA)
• Ken Sreymom, Institut Pasteur du Cambodge (KHM)
• Neung Chhoeuth, Institut Pasteur du Cambodge (KHM)
• Hok Visal, Institut Pasteur du Cambodge (KHM)
• Pring Long, Institut Pasteur du Cambodge (KHM)
• Lim Thona, Institut Pasteur du Cambodge (KHM)
• Bumrungsri Sara, Prince of Songkla University (THA)
• Duboz Raphaël, CIRAD-BIOS-UMR ASTRE (FRA) ORCID: 0000-0002-2853-6195
• Buchy Philippe, GlaxoSmithKline (SGP)
• Ly Sowath, Institut Pasteur du Cambodge (KHM)
• Duong Veasna, Institut Pasteur du Cambodge (KHM)
• Tarantola Arnaud, Institut Pasteur du Cambodge (KHM)
• Binot Aurélie, CIRAD-BIOS-UMR ASTRE (FRA) ORCID: 0000-0002-0295-4241
• Dussart Philippe, Institut Pasteur du Cambodge (KHM)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/596432/)

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