Nipah virus in lyle's flying foxes, Cambodia

Reynes Jean-Marc, Counor Dorian, Ong Sivuth, Faure Caroline, Seng Vansay, Molia Sophie, Walston Joe, Georges-Courbot Marie Claude, Deubel Vincent, Sarthou Jean-Louis. 2005. Nipah virus in lyle's flying foxes, Cambodia. Emerging Infectious Diseases, 11 (7) : pp. 1042-1047.

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Abstract : We conducted a survey in Cambodia in 2000 on henipavirus infection among several bat species, including flying foxes, and persons exposed to these animals. Among 1,072 bat serum samples tested by enzyme-linked immunosorbent assay, antibodies reactive to Nipah virus (NiV) antigen were detected only in Pteropus lylei species; Cynopterus sphinx, Hipposideros larvatus, Scotophilus kuhlii, Chaerephon plicata, Taphozous melanopogon, and T. theobaldi species were negative. Seroneutralization applied on a subset of 156 serum samples confirmed these results. None of the 8 human serum samples was NiV seropositive with the seroneutralization test. One virus isolate exhibiting cytopathic effect with syncytia was obtained from 769 urine samples collected at roosts of P. lylei specimens. Partial molecular characterization of this isolate demonstrated that it was closely related to NiV. These results strengthen the hypothesis that flying foxes could be the natural host of NiV. Surveillance of human cases should be implemented. (Résumé d'auteur)

Mots-clés Agrovoc : Paramyxoviridae, Chiroptera, Surveillance épidémiologique, Immunologie, Transmission des maladies

Mots-clés géographiques Agrovoc : Cambodge

Mots-clés complémentaires : Virus Nipah

Classification Agris : L73 - Animal diseases

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Reynes Jean-Marc, Institut Pasteur du Cambodge (KHM)
  • Counor Dorian, Institut Pasteur du Cambodge (KHM)
  • Ong Sivuth, Institut Pasteur du Cambodge (KHM)
  • Faure Caroline, Institut Pasteur (FRA)
  • Seng Vansay, Institut Pasteur du Cambodge (KHM)
  • Molia Sophie, CIRAD-EMVT-UPR Epidémiologie (GLP)
  • Walston Joe, Wildlife Conservation Society (KHM)
  • Georges-Courbot Marie Claude, Institut Pasteur (FRA)
  • Deubel Vincent, Institut Pasteur (FRA)
  • Sarthou Jean-Louis, Institut Pasteur du Cambodge (KHM)

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