Emergence and potential of high-throughput and integrative approaches in pathology tackling the adaptive evolution of pathogens

Frutos Roger, Viari Alain, Vachiery Nathalie, Boyer Frédéric, Lefrançois Thierry, Martinez Dominique. 2008. Emergence and potential of high-throughput and integrative approaches in pathology tackling the adaptive evolution of pathogens. Annals of the New York Academy of Sciences, 1149 : 62-65. Biennial Conference of the Society for Tropical Veterinary Medicine. 9, Mexico, Mexique, 17 Juin 2007/22 Juin 2007.

https://doi.org/10.1196/annals.1428.060

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Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Histoire et philosophie des sciences; Histoire, histoire de l'art, archéologie; Psychologie-éthologie-ergonomie

Résumé : In recent years a major revolution has occurred in the analysis and understanding of pathogenesis and host-pathogens/parasite interactions. This revolution has been achieved through the emergence of the high-throughput integrative approaches used in the "omics" fields-such as genomics, transcriptomics, proteomics, interactomics, and metabolomics. The novelty of these approaches has resulted from the development of high-throughput apparatus, assisted by the increasing power and software of computers that allow for high-speed, multifactorial simultaneous analysis of numerous samples. This level of integration allows for in-depth analysis ofmechanisms, pace, and patterns of the evolution and adaptation of pathogens. This evolution from linear to multifactorial approaches has opened new ways of creating and characterizing new vaccines, diagnostic candidates, and drug targets.

Mots-clés Agrovoc : relation hôte pathogène, pathologie, technique analytique, bioinformatique, changement technologique, biologie, génie génétique, innovation

Mots-clés complémentaires : Protéomique

Classification Agris : S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

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