Pathogeno-proteomics: Toward a new approach of host-vector-pathogen interactions

Holzmuller Philippe, Grébaut Pascal, Brizard Jean-Paul, Berthier David, Chantal Isabelle, Bossard Géraldine, Bucheton Bruno, Vezilier Frédéric, Chuchana Paul, Bras-Gonçalves Rachel, Lemesre Jean-Loup, Vicendeau Philippe, Cuny Gérard, Frutos Roger, Biron David George. 2008. Pathogeno-proteomics: Toward a new approach of host-vector-pathogen interactions. Annals of the New York Academy of Sciences, 1149 : 66-70. Biennial Conference of the Society for Tropical Veterinary Medicine. 9, Mexico, Mexique, 17 Juin 2007/22 Juin 2007.

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Histoire et philosophie des sciences; Histoire, histoire de l'art, archéologie; Psychologie-éthologie-ergonomie

Résumé : Many scientists working on pathogens (viruses, bacteria, fungi, parasites) are betting heavily on data generated by longitudinal genomic-transcriptomic-proteomic studies to explain biochemical host-vector-pathogen interactions and thus to contribute to disease control. Availability of genome sequences of various organisms, from viruses to complex metazoans, led to the discovery of the functions of the genes themselves. The postgenomic era stimulated the development of proteomic and bioinformatics tools to identify the locations, functions, and interactions of the gene products in tissues and/or cells of living organisms. Because of the diversity of available methods and the level of integration they promote, proteomics tools are potentially able to resolve interesting issues specific not only to host-vector-pathogen interactions in cell immunobiology, but also to ecology and evolution, population biology, and adaptive processes. These new analytical tools, as all newtools, contain pitfalls directly related to experimental design, statistical treatment, and protein identification. Nevertheless, they offer the potency of building large protein-protein interaction networks for in silico analysis of novel biological entities named "interactomes," a way of modeling host-vector-pathogen interactions to define new interference strategies.

Mots-clés Agrovoc : relation hôte pathogène, agent pathogène, technique analytique, génome, bioinformatique, génie génétique, modèle, micro-organisme

Mots-clés complémentaires : Protéomique

Classification Agris : L10 - Génétique et amélioration des animaux
H20 - Maladies des plantes

Champ stratégique Cirad : Hors axes (2005-2013)

Auteurs et affiliations

• Holzmuller Philippe, CIRAD-BIOS-UMR TRYPANOSOMES (FRA) ORCID: 0000-0002-8919-9081
• Grébaut Pascal, IRD (FRA)
• Brizard Jean-Paul, CNRS (FRA)
• Berthier David, CIRAD-BIOS-UMR TRYPANOSOMES (FRA) ORCID: 0000-0002-3283-6588
• Chantal Isabelle, CIRAD-BIOS-UMR TRYPANOSOMES (FRA) ORCID: 0000-0002-3429-484X
• Bossard Géraldine, CIRAD-BIOS-UMR TRYPANOSOMES (FRA)
• Bucheton Bruno
• Vezilier Frédéric
• Chuchana Paul
• Bras-Gonçalves Rachel
• Lemesre Jean-Loup
• Vicendeau Philippe, Université de Bordeaux II (FRA)
• Cuny Gérard, IRD (FRA)
• Frutos Roger, CIRAD-BIOS-UMR TRYPANOSOMES (FRA)
• Biron David George, Université Blaise Pascal (FRA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/547452/)

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