Clusters of autochthonous hepatitis A cases in a low endemicity area

Guis Hélène, Clerc Stéphane, Hoen B., Viel Jean-François. 2006. Clusters of autochthonous hepatitis A cases in a low endemicity area. Epidemiology and Infection, 134 (3) : pp. 498-505.

Journal article ; Article de revue à facteur d'impact
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Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Abstract : At the University Hospital of Besanc¸on (département of Doubs, France), an unusually high number of patients were hospitalized for hepatitis A during the 1999-2000 period, some of whom had not travelled abroad. This prompted us to conduct an investigation on a population basis and search for clusters of cases possibly related to local sources of contamination. Accordingly, case definition was restricted to autochthonous cases. During the 1999-2002 period, 45 autochthonous cases were classified as possibly originating from local environmental sources. A space-time scan statistic detected one most likely cluster (standardized incidence ratio 20.63, 95% confidence interval 10.6-37.1), consisting of 11 persons (of whom five children had attended the same swimming pool). It remained significant in a sensitivity analysis, strongly supporting the hypothesis of an environmental source of contamination. This study reveals the necessity of regular surveillance for hepatitis A and raises the issue of virological surveys of pool waters. (Résumé d'auteur)

Mots-clés Agrovoc : Santé publique, Hépatite

Mots-clés géographiques Agrovoc : France

Classification Agris : L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Guis Hélène, CIRAD-EMVT-UPR Epidémiologie (FRA)
  • Clerc Stéphane, Université de Franche-Conté (FRA)
  • Hoen B., Université de Franche-Conté (FRA)
  • Viel Jean-François, Université de Franche-Conté (FRA)

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