Totté Philippe, Mather Arshad, Reslan Lina, Boublik Yan, Niang Mamadou, Du Plessis Dion H., Dedieu Laurence. 2010. Identification of Mycoplasma mycoides subsp. mycoides small colony genes coding for T-cell antigens. Clinical and Vaccine Immunology, 17 (8) : 1211-1216.
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Quartile : Q2, Sujet : MICROBIOLOGY / Quartile : Q3, Sujet : INFECTIOUS DISEASES / Quartile : Q3, Sujet : IMMUNOLOGY
Résumé : Genes of the Mycoplasma mycoides subsp. mycoides small colony biotype (MmmSC) coding for proteins capable of eliciting protective T-cell memory responses have potential for incorporation into a recombinant subunit vaccine against contagious bovine pleuropneumonia (CBPP). Here we used lymphocytes from cattle that had completely recovered from infection to screen products of MmmSC genes for recognition by CD4+ effector memory (Tem) and central memory (Tcm) T lymphocytes. Six MmmSC genes (abc, gapN, glpO, lppA, lppB, and ptsG) were expressed as histidine-tagged recombinant polypeptides, or synthetic overlapping peptides, before inclusion in proliferation and gamma interferon (IFN- ) assays. Only two MmmSC antigens, LppA and PtsG, consistently induced recall proliferation from immune CD4+ T cells and IFN- production in all animals tested. Moreover, LppA and PtsG were shown to possess epitopes recognized by both short-lived CD4+ Tem and long-lived CD4+ Tcm cells.
Mots-clés Agrovoc : péripneumonie contagieuse bovine, Mycoplasma mycoides, identification, bovin, biotype, vaccin, antigène, protéine, immunologie, immunostimulant, gène
Mots-clés géographiques Agrovoc : Afrique au sud du Sahara
Classification Agris : L73 - Maladies des animaux
L10 - Génétique et amélioration des animaux
Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes
Auteurs et affiliations
- Totté Philippe, CIRAD-BIOS-UMR CMAEE (FRA)
- Mather Arshad, OVI (ZAF)
- Reslan Lina
- Boublik Yan, CNRS (FRA)
- Niang Mamadou, LCV (MLI)
- Du Plessis Dion H., OVI (ZAF)
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Dedieu Laurence, CIRAD-BIOS-UPR Bioagresseurs de pérennes (FRA)
ORCID: 0000-0002-6492-3002
Autres liens de la publication
Source : Cirad - Agritrop (https://agritrop.cirad.fr/557490/)
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