Early responses associated with chronic pathology in murine schistosomiasis

Cetre-Sossah Catherine, Montesano M.A., Freeman Jr.G.L., Willard M.T., Colley D.G., Secor W.E. 2007. Early responses associated with chronic pathology in murine schistosomiasis. Parasite Immunology, 29 (5) : 241-249.

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Inbred male CBA/J mice infected with Schistosoma mansoni develop either hypersplenomegaly syndrome (HSS) or moderate splenomegaly syndrome (MSS) by 20 weeks of infection. Pathologically and immunologically, MSS and HSS closely parallel the intestinal and hepatosplenic clinical forms of schistosomiasis in humans, respectively. By 6 weeks after infection, mice that eventually will become MSS develop T cell-stimulatory, cross-reactive idiotypes (CRI) while HSS mice never produce CRI. Because presence of CRI is useful to predict degree of chronic pathology, we used this measure to investigate what other early immunological events occurred in animals destined to develop severe morbidity. At 8 weeks of infection, there was a strong inverse correlation between CRI and splenomegaly, egg counts, and liver hydroxyproline. Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4+ T cells was inversely correlated with serum CRI and directly correlated with spleen size. In contrast, spleen cell intracellular TNF-? and peritoneal cell production of nitric oxide demonstrated positive correlations with CRI and inverse correlations with measures of morbidity. Surprisingly, IL-10 and IFN-? were not correlated with CRI levels. These studies link chronic pathology to certain immunological responses during the acute phase of schistosomiasis.

Mots-clés Agrovoc : Schistosoma mansoni, genre humain, souris, cytokine

Mots-clés géographiques Agrovoc : Géorgie

Classification Agris : L73 - Maladies des animaux
S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Cetre-Sossah Catherine, CIRAD-BIOS-UPR Contrôle des maladies (FRA)
• Montesano M.A., NCEH (USA)
• Freeman Jr.G.L.
• Willard M.T., Emory University (USA)
• Colley D.G., University of Georgia (USA)
• Secor W.E, University of Georgia (USA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/563963/)

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