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Antimicrobial activities of Dilobeia thouarsii Roemer and Schulte, a traditional medicinal plant from Madagascar

Razafintsalama Voahiraniaina, Sarter Samira, Mambu Lengo, Randrianarivo Ranjana, Petit Thomas, Rajaonarison Jean François, Mertz Christian, Rakoto Danielle, Jeannoda Victor. 2013. Antimicrobial activities of Dilobeia thouarsii Roemer and Schulte, a traditional medicinal plant from Madagascar. South African Journal of Botany, 87 : pp. 1-3.

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Quartile : Q2, Sujet : PLANT SCIENCES

Abstract : The leaves of Dilobeia thouarsii (Roemer and Schulte), a tree that is endemic to Madagascar (Proteaceae), are used in traditional Malagasy medicine to treat bacterial skin infections and wounds. This study investigated the in vitro antibacterial activities of D. thouarsii leaf extracts and identified the bioactive compounds with the aim of providing a scientific basis for its use against skin diseases. Using broth microdilution method for leaf crude extract and its compounds, we investigated inhibition of the growth of Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Enterococcus faecalis, Vibrio harveyi, Vibrio fisheri, Salmonella Typhimurium, Salmonella antarctica, Escherichia coli, and Klebsiella pneumoniae. The two purified phenolic compounds from leaf ethyl acetate extracts (1, 2) were found to be more active than the crude extract itself. The structure of the two compounds was elucidated by NMR and mass spectrometry: compound 1 was identified as 4-aminophenol and compound 2 as 4-hydroxybenzaldehyde. A marked inhibitory effect (MIC b 0.1 mg/ml) was found against S. aureus, which is a major agent in skin infections. We observed moderate activities (MIC values of between 0.1 and 0.5 mg/ml) for E. faecalis, Vibrio spp., and Bacillus spp. Neither compoundwas active against Salmonella spp., E. coli and K. pneumoniae (MICs > 1 mg/ml). To conclude, the high antimicrobial activity of D. thouarsii leaf extracts against S. aureus supports its traditional use to treat skin infections. (Résumé d'auteur)

Mots-clés Agrovoc : Proteaceae, Plante médicinale, Antimicrobien, Propriété antimicrobienne, Feuille, Extrait d'origine végétale, Composé phénolique, Staphylococcus aureus, Maladie de la peau

Mots-clés géographiques Agrovoc : Madagascar

Mots-clés complémentaires : Dilobeia thouarsii

Classification Agris : Q60 - Processing of non-food or non-feed agricultural products
000 - Other themes
L73 - Animal diseases

Champ stratégique Cirad : Hors axes (2005-2013)

Auteurs et affiliations

  • Razafintsalama Voahiraniaina, MNHN (FRA)
  • Sarter Samira, CIRAD-PERSYST-UMR Qualisud (VNM)
  • Mambu Lengo, MNHN (FRA)
  • Randrianarivo Ranjana, Université d'Antananarivo (MDG)
  • Petit Thomas, Université de la Réunion (REU)
  • Rajaonarison Jean François, IMRA (MDG)
  • Mertz Christian, CIRAD-PERSYST-UMR Qualisud (FRA)
  • Rakoto Danielle, Université d'Antananarivo (MDG)
  • Jeannoda Victor, Université d'Antananarivo (MDG)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/568378/)

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