Broad-coverage molecular epidemiology of Orientia tsutsugamushi in Thailand

Wongprompitak Patimaporn, Anukool Wichittra, Wongsawat Ekkarat, Silpasakorn Saowalak, Duong Veasna, Buchy Philippe, Morand Serge, Frutos Roger, Ekpo Pattama, Suputtamongkol Yupin. 2013. Broad-coverage molecular epidemiology of Orientia tsutsugamushi in Thailand. Infection, Genetics and Evolution, 15, spec. : 53-58. International Giardia and Cryptosporidium Conference. 4, Wellington, Afrique du Sud, 30 Janvier 2012/3 Février 2012.

https://doi.org/10.1016/j.meegid.2011.06.008

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Quartile : Q2, Sujet : INFECTIOUS DISEASES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie

Résumé : Orientia tsutsugamushi, an obligate intracellular bacterium closely related to the genus Rickettsia, is the causative agent of scrub typhus, a major cause of febrile illness in rural areas of Asia-Pacific region. Scrub typhus is transmitted by the bite of infected mites of the genus Leptotrombidium. The region of the 56-kDa TSA gene spanning from variable domain I (VDI) to variable domain IV (VDIV) was sequenced and used for genotyping 77 O. tsutsugamushi samples from human patients confirmed with scrub typhus from 2001 to 2003 and 2009 to 2010 in different regions of Thailand. These sequences were also compared to previously published 56-kDa TSA sequences. Only 4 genotypes out of 8 previously reported in Thailand were identified, i.e. Karp, JG-v, TA763 and Kato, respectively. Two strains were not associated with known genotypes but were closely related to Taiwanese strains. The Karp genotype was confirmed as the predominant clade. The JG-v and TA763 genotypes, in contrast to other studies, also were found. The genotype TA716 was not found, except for one strain previously described.

Mots-clés Agrovoc : Rickettsiales, épidémiologie, génotype, identification, antigène, phylogénie, genre humain, variation génétique

Mots-clés géographiques Agrovoc : Thaïlande

Mots-clés complémentaires : Orientia tsutsugamushi

Classification Agris : L73 - Maladies des animaux
S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

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