Agritrop
Accueil

The Trypanosoma brucei gambiense secretome impairs lipopolysaccharide-induced maturation, cytokine Production, and allostimulatory capacity of dendritic cells

Garzon Edwin, Holzmuller Philippe, Bras-Gonçalves Rachel, Vincendeau Philippe, Cuny Gérard, Lemesre Jean-Loup, Geiger Anne. 2013. The Trypanosoma brucei gambiense secretome impairs lipopolysaccharide-induced maturation, cytokine Production, and allostimulatory capacity of dendritic cells. Infection and Immunity, 81 (9) : 3300-3308.

Article de revue ; Article de revue à facteur d'impact
[img] Version publiée - Anglais
Accès réservé aux personnels Cirad
Utilisation soumise à autorisation de l'auteur ou du Cirad.
document_571642.pdf

Télécharger (1MB)

Quartile : Q1, Sujet : INFECTIOUS DISEASES / Quartile : Q2, Sujet : IMMUNOLOGY

Résumé : Trypanosoma brucei gambiense, a parasitic protozoan belonging to kinetoplastids, is the main etiological agent of human African trypanosomiasis (HAT), or sleeping sickness. One major characteristic of this disease is the dysregulation of the host immune system. The present study demonstrates that the secretome (excreted-secreted proteins) of T. b. gambiense impairs the lipopolysaccharide (LPS)-induced maturation of murine dendritic cells (DCs). The upregulation of major histocompatibility complex class II, CD40, CD80, and CD86 molecules, as well as the secretion of cytokines such as tumor necrosis factor alpha, interleukin-10 (IL-10), and IL-6, which are normally released at high levels by LPS-stimulated DCs, is significantly reduced when these cells are cultured in the presence of the T. b. gambiense secretome. Moreover, the inhibition of DC maturation results in the loss of their allostimulatory capacity, leading to a dramatic decrease in Th1/Th2 cytokine production by cocultured lymphocytes. These results provide new insights into a novel efficient immunosuppressive mechanism directly involving the alteration of DC function which might be used by T. b. gambiense to interfere with the host immune responses in HAT and promote the infectious process.

Classification Agris : L72 - Organismes nuisibles des animaux
L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Garzon Edwin, IRD (FRA)
  • Holzmuller Philippe, CIRAD-BIOS-UMR INTERTRYP (FRA) ORCID: 0000-0002-8919-9081
  • Bras-Gonçalves Rachel, IRD (FRA)
  • Vincendeau Philippe, Université de Bordeaux II (FRA)
  • Cuny Gérard, IRD (FRA)
  • Lemesre Jean-Loup, IRD (FRA)
  • Geiger Anne, IRD (FRA)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/571642/)

Voir la notice (accès réservé à Agritrop) Voir la notice (accès réservé à Agritrop)

[ Page générée et mise en cache le 2024-03-26 ]