Atypical human infections by animal trypanosomes

Truc Philippe, Büscher Philippe, Cuny Gérard, Gonzatti Marisa, Jannin Jean, Joshi Prashant, Juyal Prayag, Lun Zhao-Rong, Mattioli Raffaele C., Pays Etienne, Simarro Pere P., Geraldes Teixeiras Marta Maria, Touratier Louis, Vincendeau Philippe, Desquesnes Marc. 2013. Atypical human infections by animal trypanosomes. PLoS Neglected Tropical Diseases, 7 (9):e2208, 7 p.

Journal article ; Article de revue à facteur d'impact Revue en libre accès total
Published version - Anglais
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Quartile : Q1, Sujet : TROPICAL MEDICINE / Quartile : Q1, Sujet : PARASITOLOGY

Abstract : The two classical forms of human trypanoso- moses are sleeping sickness due to Trypanosoma brucei gambiense or T. brucei rhodesiense , and Chagas disease due to T. cruzi . However, a number of atypical human infections caused by other T. species (or sub-species) have been reported, namely due to T. brucei brucei , T. vivax , T. congolense , T. evansi , T. lewisi , and T. lewisi -like. These cases are reviewed here. Some infections were transient in nature, while others required treatments that were successful in most cases, although two cases were fatal. A recent case of infection due to T. evansi was related to a lack of apolipoprotein L-I, but T. lewisi infections were not related to immunosuppression or specific human genetic profiles. Out of 19 patients, eight were confirmed between 1974 and 2010, thanks to improved molecular techniques. However, the number of cases of atypical human trypanosomoses might be underestimated. Thus, improvement, evaluation of new diagnostic tests, and field investigations are required for detection and confirmation of these atypical cases. (Résumé d'auteur)

Mots-clés Agrovoc : Trypanosomose, Genre humain, Maladie de l'homme, Maladie des animaux, Diagnostic, Analyse du risque, Technique immunologique, Rongeur, Identification, Trypanosoma, Trypanosoma brucei, Trypanosoma evansi, Trypanosoma lewisi, Trypanosoma congolense

Mots-clés géographiques Agrovoc : Afrique, Asie, Monde

Classification Agris : L72 - Pests of animals
U30 - Research methods
L73 - Animal diseases

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Truc Philippe, IRD (FRA)
  • Büscher Philippe, Institute of tropical medecine (BEL)
  • Cuny Gérard, IRD (FRA)
  • Gonzatti Marisa, Universidad Simón Bolívar (VEN)
  • Jannin Jean, World Health Organization (CHE)
  • Joshi Prashant, Indira Gandhi Government Medical College (IND)
  • Juyal Prayag, Guru Angad University (IND)
  • Lun Zhao-Rong, Sun Yat-Sen University (CHN)
  • Mattioli Raffaele C., FAO (ITA)
  • Pays Etienne, Université de Bordeaux II (FRA)
  • Simarro Pere P., World Health Organization (CHE)
  • Geraldes Teixeiras Marta Maria, Universidade de São Paulo (BRA)
  • Touratier Louis, OIE (FRA)
  • Vincendeau Philippe, Université de Bordeaux II (FRA)
  • Desquesnes Marc, CIRAD-BIOS-UMR INTERTRYP (THA) ORCID: 0000-0002-7665-2422

Source : Cirad - Agritrop (

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