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Rodents and risk in the Mekong Delta of Vietnam: Seroprevalence of selected zoonotic viruses in rodents and humans

Van Cuong Nguyen, Carrique-Mas Juan, Be Hien Vo, Ngoc An Nguyen, Tri Tue Ngo, Lam Anh Nguyet, Hong Anh Pham, The Phuc Nguyen, Baker Stephen, Voutilainen Liina, Jääskejäinen Anne, Huhtamo Eili, Utriainen Mira, Sironen Tarja, Vaheri Antti, Henttonen Heikki, Vapalahti Olli, Chaval Yannick, Morand Serge, Bryant Juliet. 2015. Rodents and risk in the Mekong Delta of Vietnam: Seroprevalence of selected zoonotic viruses in rodents and humans. Vector Borne and Zoonotic Diseases, 15 (1) : pp. 65-72.

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Quartile : Q2, Sujet : PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH (Science) / Quartile : Q3, Sujet : INFECTIOUS DISEASES

Abstract : In the Mekong Delta in southern Vietnam, rats are commonly traded in wet markets and sold live for food consumption. We investigated seroprevalence to selected groups of rodent-borne viruses among human populations with high levels of animal exposure and among co-located rodent populations. The indirect fluorescence antibody test (IFAT) was used to determine seropositivity to representative reference strains of hantaviruses (Dobrava virus [DOBV], Seoul virus [SEOV]), cowpox virus, arenaviruses (lymphocytic choriomeningitis virus [LCMV]), flaviviruses (tick-borne encephalitis virus [TBEV]), and rodent parechoviruses (Ljungan virus), using sera from 245 humans living in Dong Thap Province and 275 rodents representing the five common rodent species sold in wet markets and present in peridomestic and farm settings. Combined seropositivity to DOBV and SEOV among the rodents and humans was 6.9% (19/275) and 3.7% (9/245), respectively; 1.1% (3/275) and 4.5% (11/245) to cowpox virus; 5.4% (15/275) and 47.3% (116/245) for TBEV; and exposure to Ljungan virus was 18.8% (46/245) in humans, but 0% in rodents. Very little seroreactivity was observed to LCMV in either rodents (1/275, 0.4%) or humans (2/245, 0.8%). Molecular screening of rodent liver tissues using consensus primers for flaviviruses did not yield any amplicons, whereas molecular screening of rodent lung tissues for hantavirus yielded one hantavirus sequence (SEOV). In summary, these results indicate low to moderate levels of endemic hantavirus circulation, possible circulation of a flavivirus in rodent reservoirs, and the first available data on human exposures to parechoviruses in Vietnam. Although the current evidence suggests only limited exposure of humans to known rodent-borne diseases, further research is warranted to assess public health implications of the rodent trade. (Résumé d'auteur)

Mots-clés Agrovoc : Rongeur, Rattus, Bandicota, Genre humain, zoonose, Flavivirus, Arenaviridae, Picornaviridae, Hantavirus, Orthopoxvirus, Sérologie, Virologie, Épidémiologie, Transmission des maladies, Maladie transmise par vecteur, Santé publique, Santé animale, Enquête pathologique, Rattus norvegicus

Mots-clés géographiques Agrovoc : Viet Nam, Mékong

Mots-clés complémentaires : Arenavirus, Bandicota indica, Rattus argentiventer, Rattus exulans, Parechovirus

Classification Agris : L72 - Pests of animals
L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Van Cuong Nguyen, Oxford University (GBR)
  • Carrique-Mas Juan, Oxford University (GBR)
  • Be Hien Vo, INRA (FRA)
  • Ngoc An Nguyen, Finnish Fisheries Research (FIN)
  • Tri Tue Ngo, Oxford University (GBR)
  • Lam Anh Nguyet, Oxford University (GBR)
  • Hong Anh Pham, Oxford University (GBR)
  • The Phuc Nguyen, Oxford University (GBR)
  • Baker Stephen, Oxford University (GBR)
  • Voutilainen Liina, Finnish Fisheries Research (FIN)
  • Jääskejäinen Anne, University of Helsinki (FIN)
  • Huhtamo Eili, University of Helsinki (FIN)
  • Utriainen Mira, University of Helsinki (FIN)
  • Sironen Tarja, University of Helsinki (FIN)
  • Vaheri Antti, University of Helsinki (FIN)
  • Henttonen Heikki, FINNIDA (FIN)
  • Vapalahti Olli, University of Helsinki (FIN)
  • Chaval Yannick, INRA (FRA)
  • Morand Serge, CIRAD-ES-UPR AGIRs (LAO) ORCID: 0000-0003-3986-7659
  • Bryant Juliet, Oxford University (GBR)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/575482/)

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