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A large-scale genomic approach affords unprecedented resolution for the molecular epidemiology and evolutionary history of contagious caprine pleuropneumonia

Dupuy Virginie, Thiaucourt François, Manso-Silvan Lucia. 2015. A large-scale genomic approach affords unprecedented resolution for the molecular epidemiology and evolutionary history of contagious caprine pleuropneumonia. In : Progress in Human and Animal Mycoplasmology. Book of abstracts. Pendik Veterinary Control Institute. Istanbul : Pendik Veterinary Control Institute, Résumé, 1 p. Progress in Human and Animal Mycoplasmology, Istanbul, Turquie, 3 June 2015/5 June 2015.

Paper with proceedings
[img] Published version - Anglais
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eMLST_Mccp_Pendik_final.pdf

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[img] Published version - Anglais
Access restricted to CIRAD agents
Use under authorization by the author or CIRAD.
Dupuy-Progress in Human and Animal Mycoplasmology.pdf

Télécharger (752kB) | Request a copy

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Abstract : Background: Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae (Mccp), is a devastating disease of domestic goats and of some wild ungulate species. The disease is currently spreading in Africa and Asia and poses a serious threat to disease-free areas. A comprehensive view of the evolutionary history and dynamics of Mccp is essential to understand the epidemiology of CCPP. Yet, analysing the diversity of genetically monomorphic pathogens, such as Mccp, is complicated due to their low variability. Objectives: In this study we investigated the molecular epidemiology and evolution of CCPP using a large-scale genomic approach. Methods: Next-generation sequencing data was used to develop a highly discriminatory multigene typing system, applied to a sample of strains representing the global distribution of CCPP. A Bayesian approach was used to infer the first robust phylogeny of Mccp and to date the principal events of its evolutionary history. Conclusions: This study shows how combining large-scale genomic data with spatial and temporal data makes it possible to obtain a comprehensive view of the epidemiology of CCPP, a precondition for the development of improved disease surveillance and control measures. (Texte intégral)

Classification Agris : L73 - Animal diseases

Auteurs et affiliations

  • Dupuy Virginie, CIRAD-BIOS-UMR CMAEE (FRA)
  • Thiaucourt François, CIRAD-BIOS-UMR CMAEE (FRA)
  • Manso-Silvan Lucia, CIRAD-BIOS-UMR CMAEE (FRA) ORCID: 0000-0002-5539-3804

Source : Cirad-Agritrop (https://agritrop.cirad.fr/576262/)

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