Maternal early pregnancy serum metabolites and risk of gestational diabetes mellitus

Enquobahrie Daniel A., Denis Marie, Tadesse Mahlet, Gelaye Bizu, Ressom Habtom W., Williams Michelle A.. 2015. Maternal early pregnancy serum metabolites and risk of gestational diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 100 (11) : pp. 4348-4356.

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Abstract : Context: Significant gaps remain in the understanding of genetic and environmental risk factors, and related mechanisms that contribute to gestational diabetes mellitus (GDM). Objectives: To investigate early pregnancy maternal serum metabolites and subsequent risk of GDM. Design: Information on participant characteristics and GDM diagnosis was collected using in-person interviews and medical record abstraction, respectively. Early pregnancy serum samples were used for non-targeted metabolite profiling using a gas chromatography-mass spectrometry platform. Lasso regression was used to select a set of metabolites that are jointly associated with GDM case-control status. We evaluated the predictive performance of the set of selected metabolites using a receiver operating characteristics curve and area under the curve (AUC). Participants: A total of 178 GDM cases and 180 controls who participated in a pregnancy cohort study. Results: A set of 17 metabolites (linoleic acid, oleic acid, myristic acid, d-galactose, d-sorbitol, o-phosphocolamine, l-alanine, l-valine, 5-hydroxy-l-tryptophan, l-serine, sarcosine, l-pyroglutamic acid, l-mimosine, l-lactic acid, glycolic acid, fumaric acid, and urea) differentiated GDM cases from controls. Fold changes of relative abundance of these metabolites among GDM cases compared to controls ranged from 1.47 (linoleic acid) to 0.78 (5-hydroxy-l-tryptophan). Addition of these selected metabolites to a set of well-known GDM risk factors improved the AUC significantly from 0.71 to 0.87 (p-value=3.97e-07). Conclusions: We identified combinations of metabolites in early pregnancy that are associated with subsequent risk of GDM. Replication of findings may improve understanding of GDM pathogenesis and may have implications for the design of GDM prevention and early diagnosis protocols. (Résumé d'auteur)

Mots-clés Agrovoc : Diabète, Gestation, Femme, Maladie de l'homme, Métabolite, Sérum sanguin, Diagnostic précoce, Facteur de risque, Gestion du risque, Épidémiologie

Mots-clés géographiques Agrovoc : États-Unis

Classification Agris : L51 - Animal physiology - Nutrition
L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Hors axes (2014-2018)

Auteurs et affiliations

  • Enquobahrie Daniel A., University of Washington (USA)
  • Denis Marie, CIRAD-BIOS-UMR AGAP (FRA)
  • Tadesse Mahlet, CIRAD-ES-UPR BSef (FRA)
  • Gelaye Bizu, Havard University (USA)
  • Ressom Habtom W., Georgetown University (USA)
  • Williams Michelle A., Havard University (USA)

Source : Cirad-Agritrop (

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