The biosynthesis of albicidins

Petras Daniel, Hempel Benjamin, Kerwat Dennis, Mainz Andi, Cociancich Stéphane, Royer Monique, Süssmuth Roderich. 2015. The biosynthesis of albicidins. . Francfort : DECHEMA, Résumé, 1 p. European Conference on Natural Products. 2, Francfort, Allemagne, 6 September 2015/9 September 2015.

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Abstract : Albicidins, produced by the sugarcane pathogenic bacterium Xanthomonas albilineans, are potent inhibitors of the bacterial DNA gyrase with Ic50values in nM ranges [1].The structure of albicidins remained unclear for more than three decades after their first description by Birch et al. [2]. After the identification and sequencing of three gene islands, responsible for the albicidin biosynthesis, a PKS-NRPS hybrid, build up by three enzymes, Alb01, Alb05and Alb09 was proposed for the albicidin assembly [3, 4].Most recently we were able to solve the hitherto unknown structure of the main albicidin [5,6] and post NRPS modified derivatives, revealing a unique polyaromatic oligopeptide mainly composed of p-amino benzoic acids. Our in-vitro studies of the non-ribosomal albicidin assembly line and tailoring enzymes provide detailed insights into the biosynthetic machinery of albicidins. Together with our bioinformatic investigations we are able to propose a comprehensive biochemical assembly, expanding the non-ribosomal code of adenylation domains with p-amino benzoic acid derivatives. Furthermore our study revealed a new type of dehydratase domain responsible for the in situ formation and incorporation of cyano-alanine [6]. (Texte intégral)

Classification Agris : H20 - Plant diseases

Auteurs et affiliations

  • Petras Daniel, Technische Universitaet Berlin (DEU)
  • Hempel Benjamin, Technische Universitaet Berlin (DEU)
  • Kerwat Dennis, Technische Universitaet Berlin (DEU)
  • Mainz Andi, Technische Universitaet Berlin (DEU)
  • Cociancich Stéphane, CIRAD-BIOS-UMR BGPI (FRA)
  • Royer Monique, CIRAD-BIOS-UMR BGPI (FRA)
  • Süssmuth Roderich, Technische Universitaet Berlin (DEU)

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