A clinical and epidemiological investigation of the first reported human infection with the zoonotic parasite Trypanosoma evansi in Southeast Asia

Van Vinh Chau Nguyen, Buu Chau Le, Desquesnes Marc, Herder Stéphane, Phu Huong Lan Nguyen, Campbell James, Van Cuong Nguyen, Yimming Benjarat, Chalermwong Piangjai, Jittapalapong Sathaporn, Ramon Franco Jose, Tri Tue Ngo, Rabaa Maia A., Carrique-Mas Juan, Pham Thi Thanh Tam, Tran Vu Thieu Nga, Berto Alessandra, Thi Hoa Ngo, Van Minh Hoang Nguyen, Canh Tu Nguyen, Khac Chuyen Nguyen, Wills Bridget, Tinh Hien Tran, Thwaites Guy E., Yacoub Sophie, Baker Stephen. 2016. A clinical and epidemiological investigation of the first reported human infection with the zoonotic parasite Trypanosoma evansi in Southeast Asia. Clinical Infectious Diseases, 62 (8) : pp. 1002-1008.

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Quartile : Outlier, Sujet : INFECTIOUS DISEASES / Quartile : Outlier, Sujet : MICROBIOLOGY / Quartile : Q1, Sujet : IMMUNOLOGY

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Abstract : Background. Trypanosoma is a genus of unicellular parasitic flagellate protozoa. Trypanosoma brucei species and Trypanosoma cruzi are the major agents of human trypanosomiasis; other Trypanosoma species can cause human disease, but are rare. In March 2015, a 38-year-old woman presented to a healthcare facility in southern Vietnam with fever, headache, and arthralgia. Microscopic examination of blood revealed infection with Trypanosoma. Methods. Microscopic observation, polymerase chain reaction (PCR) amplification of blood samples, and serological testing were performed to identify the infecting species. The patient's blood was screened for the trypanocidal protein apolipoprotein L1 (APOL1), and a field investigation was performed to identify the zoonotic source. Results. PCR amplification and serological testing identified the infecting species as Trypanosoma evansi. Despite relapsing 6 weeks after completing amphotericin B therapy, the patient made a complete recovery after 5 weeks of suramin. The patient was found to have 2 wild-type APOL1 alleles and a normal serum APOL1 concentration. After responsive animal sampling in the presumed location of exposure, cattle and/or buffalo were determined to be the most likely source of the infection, with 14 of 30 (47%) animal blood samples testing PCR positive for T. evansi. Conclusions. We report the first laboratory-confirmed case of T. evansi in a previously healthy individual without APOL1 deficiency, potentially contracted via a wound while butchering raw beef, and successfully treated with suramin. A linked epidemiological investigation revealed widespread and previously unidentified burden of T. evansi in local cattle, highlighting the need for surveillance of this infection in animals and the possibility of further human cases. (Résumé d'auteur)

Mots-clés Agrovoc : Trypanosoma evansi, Maladie de l'homme, zoonose, Épidémiologie, Parasitologie, Étude de cas, Enquête pathologique

Mots-clés géographiques Agrovoc : Viet Nam, Asie du Sud-Est

Mots-clés complémentaires : Émergence

Classification Agris : L72 - Pests of animals
L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Van Vinh Chau Nguyen, Hospital for Tropical Diseases (VNM)
  • Buu Chau Le, Hospital for Tropical Diseases (VNM)
  • Desquesnes Marc, CIRAD-BIOS-UMR INTERTRYP (THA) ORCID: 0000-0002-7665-2422
  • Herder Stéphane, IRD (FRA)
  • Phu Huong Lan Nguyen, Hospital for Tropical Diseases (VNM)
  • Campbell James, Oxford University (GBR)
  • Van Cuong Nguyen, Oxford University (GBR)
  • Yimming Benjarat, Kasetsart University (THA)
  • Chalermwong Piangjai, Kasetsart University (THA)
  • Jittapalapong Sathaporn, Kasetsart University (THA)
  • Ramon Franco Jose, World Health Organization (CHE)
  • Tri Tue Ngo, Oxford University (GBR)
  • Rabaa Maia A., Oxford University (VNM)
  • Carrique-Mas Juan, Oxford University (GBR)
  • Pham Thi Thanh Tam, Oxford University (VNM)
  • Tran Vu Thieu Nga, Oxford University (VNM)
  • Berto Alessandra, Oxford University (VNM)
  • Thi Hoa Ngo, Oxford University (VNM)
  • Van Minh Hoang Nguyen, Oxford University (VNM)
  • Canh Tu Nguyen, APHCA (VNM)
  • Khac Chuyen Nguyen, DAH (VNM)
  • Wills Bridget, Oxford University (VNM)
  • Tinh Hien Tran, Oxford University (VNM)
  • Thwaites Guy E., Oxford University (VNM)
  • Yacoub Sophie, Oxford University (VNM)
  • Baker Stephen, Oxford University (GBR)

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