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Zoonotic trypanosomes in South East Asia: Attempts to control Trypanosoma lewisi using veterinary drugs

Desquesnes Marc, Yangtara Sarawut, Kunphukhieo Pawinee, Chalermwong Piangjai, Jittapalapong Sathaporn, Herder Stéphane. 2016. Zoonotic trypanosomes in South East Asia: Attempts to control Trypanosoma lewisi using veterinary drugs. Experimental Parasitology, 165 : pp. 35-42.

Journal article ; Article de revue à facteur d'impact
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Quartile : Q3, Sujet : PARASITOLOGY

Abstract : A growing number of atypical human infections due to the livestock parasite Trypanosoma evansi, or to the rat parasite Trypanosoma lewisi, are reported in humans in Asia. In some cases, clinical evolutions request treatments, however, so far, there were very few attempts to control T. lewisi using trypanocidal drugs. In a study published elsewhere, the efficacy of human trypanocides is evaluated in laboratory rats, and it concludes that none of them is able to cure rats experimentally infected with T. lewisi. Control of T. lewisi in rat would be a step for identification of drugs against this parasite. In the present study, 4 veterinary drugs: diminazene aceturate, isometamidium chloride, melarsomine hydrochloride and quinapyramine sulfate and chloride, were evaluated at low and high doses, in intra-muscular injections to normal rats experimentally infected with a stock of T. lewisi from Thailand. None of these treatments being efficient, a trial was also made using melarsomine hydrochloride in T. evansi infected rats and in mixed T. lewisi and T. evansi infected rats, in order to demonstrate the efficacy of the drugs under the present protocol. T. evansi was cleared from the rat's blood the day after the treatment, while, T. lewisi remained unaffected until the end of the experiment. These observations clearly demonstrated the efficacy of melarsomine hydrochloride against T. evansi and its inefficacy against T. lewisi. In conclusion none of the veterinary drugs was efficient against this stock of T. lewisi. Other protocols using higher doses or other drugs and T. lewisi stocks should be investigated in further studies. The control of T. lewisi infection in Wistar rats, using veterinary trypanocidal drugs, remains so far unsuccessful. (Résumé d'auteur)

Mots-clés Agrovoc : Trypanosoma lewisi, Trypanosoma evansi, Contrôle de maladies, Maladie de l'homme, Genre humain, Rongeur, Rodentia, Médicament, Efficacité d'utilisation, Lutte chimique, Parasitologie, Infection

Mots-clés géographiques Agrovoc : Asie du Sud-Est, Thaïlande

Mots-clés libres : Trypanosoma lewisi, Rats, Veterinary trypanocides, Efficacy, Trypanosoma evansi

Classification Agris : L72 - Pests of animals
L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Desquesnes Marc, CIRAD-BIOS-UMR INTERTRYP (THA) ORCID: 0000-0002-7665-2422
  • Yangtara Sarawut, Kasetsart University (THA)
  • Kunphukhieo Pawinee, Kasetsart University (THA)
  • Chalermwong Piangjai, Kasetsart University (THA)
  • Jittapalapong Sathaporn, Kasetsart University (THA)
  • Herder Stéphane, IRD (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/580434/)

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