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Trypanosome-induced Interferon-γ production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections

Ilboudo Hamidou, Jamonneau Vincent, Koffi Mathurin, Kaboré Jacques, Amoussa Roukiyath, Holzmuller Philippe, Garcia André, Bucheton Bruno, Courtin David. 2016. Trypanosome-induced Interferon-γ production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections. Microbes and Infection, 18 (6) : pp. 436-440.

Journal article ; Article de revue à facteur d'impact
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Quartile : Q3, Sujet : MICROBIOLOGY / Quartile : Q3, Sujet : INFECTIOUS DISEASES / Quartile : Q3, Sujet : IMMUNOLOGY

Abstract : Control of human African trypanosomiasis (HAT) is highly dependent on the ability to detect and treat infected individuals. However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels in blood. They are long-term potential reservoirs and thus a threat for control strategies. Cytokine responses in whole blood stimulation assays were quantified in individuals with contrasting HAT status. Trypanosome-induced IFN-γ production was only observed in “trypanotolerant” subjects suspected of harboring latent infections. This result contributes new insights into the immune responses associated with infection control and opens novel diagnosis perspectives regarding HAT elimination. (Résumé d'auteur)

Mots-clés Agrovoc : Trypanosoma brucei, Maladie de l'homme, Tolérance, Cytokine, Immunologie, Contrôle de maladies, Sang, Diagnostic, Interféron, Réponse immunitaire

Mots-clés géographiques Agrovoc : Côte d'Ivoire

Mots-clés libres : Human African trypanosomiasis, Trypanotolerance, Cytokines, IFN-γ, Whole blood stimulation

Classification Agris : L73 - Animal diseases
000 - Other themes
L72 - Pests of animals

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

  • Ilboudo Hamidou, CIRDES (BFA)
  • Jamonneau Vincent, CIRDES (BFA)
  • Koffi Mathurin, Université Jean Lorougnon Guédé (CIV)
  • Kaboré Jacques, CIRDES (BFA)
  • Amoussa Roukiyath, CERPAGE (BEN)
  • Holzmuller Philippe, CIRAD-BIOS-UMR CMAEE (FRA) ORCID: 0000-0002-8919-9081
  • Garcia André, CERPAGE (BEN)
  • Bucheton Bruno, IRD (FRA)
  • Courtin David, CERPAGE (BEN)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/580617/)

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